CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1020
Family Name Eptazocine Hbr family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00119836 Functional Category Approved Drug
Superfamily Opioid receptor ligand Tapentadol Superfamily
Class Class 62

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
D(2) dopamine receptor Ligand N-0923 Family 6 41
D(3) dopamine receptor Ligand U-99194A Family 7 33
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Histamine H3 receptor ligand SureCN6071181 family 2 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand Biom... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
D(1A) dopamine receptor and D(1B) dopamine receptor ligand N-[... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00119836 DNAP001502 Approved Drug Eptazocine hbr
CFAMM00119844 CHEMBL1744078 Bioactive (5R)-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrochloride
CFAMM00119833 CHEMBL1628589 Bioactive Sch 23982

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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