CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1056
Family Name Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family
No. of Seeds 8 No. of Other Members 20
Family Centroid CFAMM00121078 Functional Category Approved Drug
Superfamily Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Acetylcholinesterase and Cholinesterase Inhibitor 1,4-di(berbe... 5 0
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Cannabinoid receptor 1 ligand AGN-PC-088XYA family 4 6
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 2 10
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 2 2


External ID

Functional Category

Molecule Name

CFAMM00121078 DNAP001599 Approved Drug Sanguinarine
CFAMM00121054 DNC014189 Investigative Drug 9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide
CFAMM00121068 DNC014369 Investigative Drug 9-O-[3-(Phenylamino)propyl]-berberine bromide
CFAMM00121053 DNC014188 Investigative Drug 9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide
CFAMM00121067 DNC014368 Investigative Drug 9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide
CFAMM00121056 DNC014187 Investigative Drug 9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide
CFAMM00121055 DNC014186 Investigative Drug 9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide
CFAMM00121063 DNC014190 Investigative Drug 9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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