CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Sodium/potassium-transporting ATPase Inhibitor Cardiac glycosides Digoxin Family
No. of Seeds 19 No. of Other Members 97
Family Centroid CFAMM00021194 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Sodium/potassium-transporting ATPase Binder Superfamily
Class Class 101

Cousin Family NamesSeedsMembers
Elongation factor G Inhibitor Fusidic Acid Family 3 34
Neoandrographolide family 1 31
Convallatoxin family 2 11
Sodium channel protein type 10 subunit alpha Ligand SCH-725737... 2 2
Phospholipase A2 Inhibitor Petrosaspongiolide M Family 1 0
Phospholipase A2 and Phospholipase A2, membrane associated Inh... 3 8
Tubulin--tyrosine ligase inhibitor (1R,4aS,5R,6R,8S,8aR)-6,8-d... 2 35
Transcription factor AP-1 inhibitor 6R-senecionylchaparrin family 1 19


External ID

Functional Category

Molecule Name

CFAMM00021630 DNAP001625 Approved Drug Lanatoside c
CFAMM00021122 DNAP001594 Approved Drug Alpha-acetyldigoxin
CFAMM00021602 DAP000120 Approved Drug Digitoxin
CFAMM00021392 DNAP001629 Approved Drug Digitalin
CFAMM00021805 DAP000465 Approved Drug Ouabain
CFAMM00021194 DAP000744 Approved Drug Digoxin
CFAMM00021804 DAP000464 Approved Drug Deslanoside
CFAMM00021632 DNAP001627 Approved Drug Lanatoside a
CFAMM00021467 DAP000119 Approved Drug Acetyldigitoxin
CFAMM00020984 DNAP001542 Approved Drug Beta-acetyldigoxin
CFAMM00021631 DNAP001626 Approved Drug Lanatoside b
CFAMM00021670 CHEMBL2029041 Bioactive 3-[3-[[(2S,3R,4R,6S)-6-[[(2S,3R,4R,6S)-3,4-dihydroxy-6-[[(2S,3R,4R,6S)-3,4,6-trihydroxyoxan-2-yl]methoxy]oxan-2-yl]methoxy]-3,4-dihydroxyoxan-2-yl]methoxy]-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
CFAMM00021775 CHEMBL1651648 Bioactive CHEBI:71000
CFAMM00021482 CHEMBL1651624 Bioactive Beta-D-Digitoxose
CFAMM00021344 CHEMBL254219 Bioactive digitoxin
CFAMM00021512 CHEMBL96600 Bioactive AGN-PC-074Q2A
CFAMM00021176 CHEMBL2092909 Bioactive 3-[(3S,8R,9S,10S,13R,14R,17S)-14-hydroxy-10,13-dimethyl-3-[[(2R,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy]-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
CFAMM00021678 CHEMBL2092738 Bioactive 3-[(3S,8R,9S,10S,13R,14R,17R)-14-hydroxy-10,13-dimethyl-3-[[(2R,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy]-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
CFAMM00021671 CHEMBL2029042 Bioactive 3-[14-hydroxy-10,13-dimethyl-3-[[(2S,3R,4R,6S)-3,4,6-trihydroxyoxan-2-yl]methoxy]-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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