CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1060
Family Name Hydrastine family
No. of Seeds 6 No. of Other Members 115
Family Centroid CFAMM00121446 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Hydrastine Superfamily
Class Class 92

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Elongation factor 1A Inhibitor Narciclasine Family 1 0
Cytochrome P450 3A4 Inhibitor 1,2-diacetoxylycorine Family 4 19
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Sodium-dependent serotonin transporter inhibitor AGN-PC-075EZ8... 5 5
Sodium-dependent serotonin transporter inhibitor AGN-PC-075EYN... 1 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075EXY... 3 0
Stilbenes Metabolite Narceine Family 1 7
Stilbenes Metabolite (Z)-Narceine imide Family 1 1


External ID

Functional Category

Molecule Name

CFAMM00121447 DNAP001674 Approved Drug Noscapine (narcotine)
CFAMM00121446 DNAP001604 Approved Drug Hydrastine
CFAMM00121431 CHEMBL475536 Bioactive (+/-)-hydrastine
CFAMM00121430 DNCL002489 Clinical Trial Drug CB3304
CFAMM00121467 DNC000319 Investigative Drug Bicuculline
CFAMM00121418 DNC001027 Investigative Drug N-methylbicuculline

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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