CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1062
Family Name Danthron family
No. of Seeds 11 No. of Other Members 141
Family Centroid CFAMM00121537 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Danthron Superfamily
Class Class 779

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Retinoid X receptor Ligand Bexarotene Family 7 492
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand Dienestrol Family 35 440
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Chromomycin A3 family 7 14
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Substance-P receptor Ligand CI-1021 Family 1 0
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Apoptosis regulator Bcl-2 Inhibitor Gossypol Family 1 9
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
DNA topoisomerase 2-beta Inhibitor Demethylzeylasterone Family 1 2
Indoleamine 2,3-dioxygenase 1 Inhibitor Annulin C Family 2 3
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Indoleamine 2,3-dioxygenase 1 Inhibitor Garveatin E Family 2 0
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Isocitrate lyase Inhibitor Bis(3-bromo-4,5-dihydroxyphenyl)met... 1 2
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Estrogen receptor beta and Estrogen receptor ligand 4-bromo-9a... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Thioredoxin glutathione reductase and Voltage-dependent N-type... 1 3
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-benzyl-3,17-... 1 1
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 4 0
RAC-alpha serine/threonine-protein kinase inhibitor CHEMBL4933... 1 3
Tyrosine-protein kinase Lck inhibitor ZINC03370948 family 3 0
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 6 13
Nuclear receptor ROR-gamma and Huntingtin ligand CHEMBL1568747... 1 3
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 2
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Solute carrier organic anion transporter family member 1B1 and... 1 0
Catechol O-methyltransferase inhibitor 4,5-dihydroxybenzene-1,... 1 1
Sterol O-acyltransferase 1 and Sterol O-acyltransferase 2 inhi... 1 5
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
5-lipoxygenase inhibitor 6-(1,8-dihydroxy-9-oxo-10H-anthracen-... 6 0
Aldehyde dehydrogenase, cytosolic 1 and Aldehyde dehydrogenase... 2 0
72 kDa type IV collagenase inhibitor [(2S,3S,4R)-4-(4,5-dihydr... 1 0
Benzopyrans Metabolite (-)-trans-3,4-Dihydro-4,8-dihydroxy-3-m... 1 0
Benzofurans Metabolite 4-Hydroxyphthalide Family 1 1
Acenes Metabolite 2,3-Epoxysesamone Family 1 0
Acenes Metabolite Lacinilene C Family 2 3
Acenes Metabolite 3-Hydroxy-9-(4-hydroxyphenyl)-1H,3H-naphtho[... 1 0
Prenol Lipids Metabolite Rosmadial Family 1 0
Acenes Metabolite Musanolone D Family 2 1
Putative NP ZINC49600254 Family 8 2
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
Putative NP ZINC12652697 Family 8 1
Putative NP ZINC03197541 Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00121537 DNAP001607 Approved Drug Danthron
CFAMM00121524 DCL000443 Clinical Trial Drug Avastin+/-Tarceva
CFAMM00121745 DNC001184 Investigative Drug Quinizarin
CFAMM00121735 DNC011453 Investigative Drug 1,5-Dihydroxy-10H-anthracen-9-one
CFAMM00121702 DNC011464 Investigative Drug 1,2-Dihydroxy-10H-anthracen-9-one
CFAMM00121574 DNC011489 Investigative Drug 4,5-Dihydroxy-10H-anthracen-9-one
CFAMM00121701 DNC011468 Investigative Drug 1-Hydroxy-10H-anthracen-9-one
CFAMM00121514 DNC012837 Investigative Drug SCH-68631
CFAMM00121546 DNC014837 Investigative Drug aloe-emodin
CFAMM00121511 DNC000075 Investigative Drug 5,8-Dihydroxy-1,4-naphthoquinone
CFAMM00121588 DNC001134 Investigative Drug Plumbagin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48686 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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