CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1070
Family Name Salicin family
No. of Seeds 5 No. of Other Members 629
Family Centroid CFAMM00124737 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Salicin Superfamily
Class Class 785

Cousin Family NamesSeedsMembers
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family 32 52
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Glucokinase Inhibitor R7201 Family 22 105
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
TS-071 family 8 36
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Sodium-dependent noradrenaline transporter Inhibitor Polygalat... 2 87
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Neutrophil elastase Inhibitor E-6-o-p-methoxycinnamoyl Scandos... 2 68
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Protein kinase C theta type and Protein kinase C eta type inhi... 7 4
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Low affinity sodium-glucose cotransporter and Sodium/glucose c... 1 0
Heat shock protein HSP 90-alpha inhibitor Catalposide family 5 22
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
Acetylcholinesterase inhibitor (2R,3S,4S,5R,6S)-2-(hydroxymeth... 1 1
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Aflatoxins Metabolite Aflatoxin B2a Family 11 1
Glycosyl Compounds Metabolite Taxiphyllin Family 2 9
Disaccharides Metabolite (Z)-N-[(4-hydroxyphenyl)methyl]ethoxy... 1 1
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Benzoxepines Metabolite Enokipodin A Family 1 0
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
Sugar Acids and Derivatives Metabolite Phenylglucuronide Family 2 6
Toluenes Metabolite Tolualdehyde glyceryl acetal Family 3 5
Putative NP ZINC35270729 Family 12 0
Putative NP ZINC04010947 Family 15 3
3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole NP (3ar,5r,6s,6ar)... 18 6
2-(6-bromonaphthalen-2-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-tri... 4 0
4-acetylphenyl (1'S,2'R,6'R,9'R)-dispiro[cyclohexane-1,4'-[3,5... 4 2
2-(4-bromophenoxy)-6-(iodomethyl)oxane-3,4,5-triol NP (2s,3r,4... 7 1
NP Chemdiv1 023678 Family 4 3
3-[7-[(4-bromo-2-fluorophenyl)methoxy]-4-methyl-2-oxochromen-3... 5 0
NP (2r,3r,4s,5r,6s)-2-(acetoxymethyl)-6-(2-propionylphenoxy)te... 2 3
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
Putative NP ZINC08382321 Family 8 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00124737 DNAP001622 Approved Drug Salicin
CFAMM00123719 CHEMBL1393422 Bioactive MUGA
CFAMM00123869 CHEMBL1172750 Bioactive 28541-83-5
CFAMM00123544 CHEMBL447016 Bioactive SureCN2577336
CFAMM00124632 DNC008787 Investigative Drug SERGLIFLOZIN A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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