CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1092
Family Name Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family
No. of Seeds 8 No. of Other Members 265
Family Centroid CFAMM00125836 Functional Category Approved Drug with Natural Product
Superfamily Amyloid beta A4 protein Inhibitor Florbetapir F-18 Superfamily
Class Class 796

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Nuclear factor NF-kappa-B p100 subunit Inhibitor GMX1777 Family 3 7
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
SB1518 family 7 103
Apricoxib family 8 77
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Nicotinic acetylcholine receptor Ligand SIB-1663 Family 1 0
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(4-f... 2 5
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Transient receptor potential cation channel subfamily V member... 2 12
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
D(2) dopamine receptor ligand 129722-25-4 family 2 2
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 7 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Metabotropic glutamate receptor 2 ligand SureCN6733905 family 11 8
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Cytochrome P450 1A2 inhibitor 1-[3-[(3R)-1-(dimethylsulfamoyl)... 1 0
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 3 6
Transient receptor potential cation channel subfamily V member... 3 2
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Histone deacetylase 1 inhibitor 7-[3-fluoro-4-[[3-hydroxy-5-(h... 2 1
Small conductance calcium-activated potassium channel protein ... 2 2
Hormone-sensitive lipase inhibitor AGN-PC-046LTD family 3 8
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-[4-... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
P2X purinoceptor 7 inhibitor 3-[1-[4-(3-nitrophenyl)phenoxy]-4... 1 1
Small conductance calcium-activated potassium channel protein ... 1 1
Histidine-rich protein PFHRP-II inhibitor AGN-PC-075SYG family 1 0
5-hydroxytryptamine receptor 1A ligand (1S,5R)-8-[[(3S)-5-meth... 2 0
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Huntingtin and Nuclear receptor ROR-gamma ligand CHEMBL1324975... 1 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[(3R)... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-0A9UZU fa... 3 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 2 0
Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... 1 1
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
dimethyl-4-[[4-(2-pyridin-4-ylethyl)piperazin-4-ium-1-yl]methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00125836 DNAP001682 Approved Drug Florbetapir F-18
CFAMM00125734 DNC010335 Investigative Drug 3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine
CFAMM00125732 DNC010331 Investigative Drug 2-phenoxy-3-(piperidin-4-yl)pyridine
CFAMM00125829 DNC007114 Investigative Drug N-(4-(benzyloxy)phenethyl)pyridin-4-amine
CFAMM00125731 DNC010332 Investigative Drug 2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine
CFAMM00125576 DNC010428 Investigative Drug nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime
CFAMM00125575 DNC010429 Investigative Drug nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime
CFAMM00125735 DNC010334 Investigative Drug 2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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