CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1096
Family Name Sodium-dependent dopamine transporter Inhibitor Ioflupane I-123 Family
No. of Seeds 130 No. of Other Members 181
Family Centroid CFAMM00126118 Functional Category Approved Drug with Natural Product
Superfamily Sodium-dependent dopamine transporter Inhibitor Ioflupane I-123 Superfamily
Class Class 799

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Muscarinic acetylcholine receptor M2 ligand Tropane alkaloid S... 7 16
Muscarinic acetylcholine receptor M5 ligand Tropane alkaloid A... 18 12
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Mu-type opioid receptor Ligand Anileridine Family 3 18
Mu-type opioid receptor Ligand Diphenoxylate Family 5 6
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 8 30
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 11 20
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 32
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 8
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Muscarinic acetylcholine receptor M3 ligand (1,1-dimethylpiper... 7 1
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 1 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 0
Sodium-dependent dopamine transporter and Transporter inhibito... 1 0
Neprilysin inhibitor (2S)-2-[[1-[3-(4-fluorophenyl)propylcarba... 2 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 7 2
Transporter and Sodium-dependent serotonin transporter inhibit... 8 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 11 2
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Sodium-dependent serotonin transporter and Transporter inhibit... 2 4
Neprilysin inhibitor SureCN7437961 family 2 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Transporter and Sodium-dependent serotonin transporter inhibit... 4 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter inhibitor 2-(4-aminophen... 5 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 4
Transporter and Sodium-dependent dopamine transporter inhibito... 1 5
Sodium-dependent dopamine transporter inhibitor methyl (1R,3S)... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 1
Sodium-dependent dopamine transporter inhibitor 2-(4-nitrophen... 2 1
Sodium-dependent dopamine transporter and Transporter inhibito... 1 1
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 17 43
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor me... 2 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 10 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
2,2-diphenylcyclopropane-1-carboxylate NP ZINC04029406 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00126118 DNAP001686 Approved Drug Ioflupane i-123
CFAMM00126101 CHEMBL186306 Bioactive AGN-PC-01LWHF
CFAMM00125956 CHEMBL2310874 Bioactive methyl (5R)-8-methyl-3-naphthalen-2-yl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125969 CHEMBL82946 Bioactive propan-2-yl (1R,3S,4S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126140 CHEMBL192195 Bioactive AGN-PC-006CFM
CFAMM00125902 CHEMBL318961 Bioactive AGN-PC-04TNRR
CFAMM00126047 CHEMBL2112877 Bioactive propan-2-yl (1R,3S,4S)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126087 CHEMBL2112946 Bioactive methyl (1R,3S,4S)-8-methyl-3-[(E)-2-phenylethenyl]-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125981 CHEMBL200748 Bioactive AGN-PC-075YQJ
CFAMM00125994 CHEMBL358006 Bioactive methyl 8-(2-fluoroethyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126106 CHEMBL356166 Bioactive AGN-PC-075SCL
CFAMM00125987 CHEMBL126410 Bioactive AGN-PC-03WEEX
CFAMM00126119 CHEMBL610894 Bioactive SureCN14173855
CFAMM00126086 CHEMBL2112945 Bioactive methyl (1R,3R,4S)-8-methyl-3-(2-phenylethyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125907 CHEMBL242338 Bioactive methyl (1R,3S,4S,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126052 CHEMBL318138 Bioactive SureCN6767838
CFAMM00126079 CHEMBL23714 Bioactive AGN-PC-076HOC
CFAMM00126105 CHEMBL353333 Bioactive SureCN14184101
CFAMM00126058 CHEMBL230000 Bioactive 2-fluoroethyl 3-[4-[(Z)-2-iodoethenyl]phenyl]-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126072 CHEMBL606934 Bioactive SureCN14173840
CFAMM00126085 CHEMBL41966 Bioactive methyl (1R,4S)-8-(2-fluoroethyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126111 CHEMBL311347 Bioactive methyl (1R,3S,4S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126104 CHEMBL14391 Bioactive ACMC-20a75z
CFAMM00125946 CHEMBL1947088 Bioactive methyl (1S,3S,4S,5R)-3-(4-methylphenyl)-8-[(Z)-4,4,4-trifluoro-2-iodobut-2-enyl]-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126057 CHEMBL126772 Bioactive AGN-PC-03WEF1
CFAMM00126071 CHEMBL309635 Bioactive propan-2-yl (1R,3S,4S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125985 CHEMBL394157 Bioactive methyl (1R,3R,4S,5R)-3-(4-ethenylphenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126011 CHEMBL1947098 Bioactive methyl (1S,3S,4S,5R)-8-[(E)-4-fluorobut-2-enyl]-3-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126024 CHEMBL398370 Bioactive methyl (1R,3R,4S,5R)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125952 CHEMBL1944824 Bioactive methyl (1S,3S,4S,5R)-8-[(E)-4-fluorobut-2-enyl]-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125978 CHEMBL41141 Bioactive methyl (1R,4S)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125932 CHEMBL14613 Bioactive AC1NONXU
CFAMM00125945 CHEMBL1947086 Bioactive methyl (1S,3S,4S,5R)-8-[(E)-4-fluorobut-2-enyl]-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126136 CHEMBL2310867 Bioactive methyl (3S,5R)-8-methyl-3-naphthalen-2-yl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125925 CHEMBL290970 Bioactive methyl (1R,4S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125984 CHEMBL14305 Bioactive methyl 3-[4-[(Z)-2-bromoethenyl]phenyl]-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125997 CHEMBL87567 Bioactive AGN-PC-00ORUG
CFAMM00126070 CHEMBL275212 Bioactive methyl 3-[4-[(Z)-2-iodoethenyl]phenyl]-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126083 CHEMBL2314215 Bioactive 2-fluoroethyl (1R,3S,4S,5R)-3-[4-[(Z)-2-iodoethenyl]phenyl]-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125938 CHEMBL2112045 Bioactive methyl (1R,3R,4R)-8-methyl-3-naphthalen-2-yl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125990 CHEMBL318755 Bioactive SureCN12643377
CFAMM00126036 CHEMBL203299 Bioactive AGN-PC-075YQQ
CFAMM00126122 CHEMBL14924 Bioactive AGN-PC-0746TF
CFAMM00126135 CHEMBL105693 Bioactive 3-fluoropropyl 3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00125931 CHEMBL356652 Bioactive AGN-PC-00GEJA
CFAMM00126042 CHEMBL430504 Bioactive 3-fluoropropyl 8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126102 CHEMBL1812740 Bioactive cyclobutyl (1S,3S,4S,5R)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126115 CHEMBL150084 Bioactive AGN-PC-075S9I
CFAMM00126108 CHEMBL2112889 Bioactive SureCN14173842
CFAMM00125963 CHEMBL1945779 Bioactive methyl (1S,3S,4S,5R)-8-(4-fluorobut-2-ynyl)-3-phenyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126022 CHEMBL2079541 Bioactive methyl (1R,3S,4S,5R)-3-(4-fluorophenyl)-8-(tritritiomethyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126082 CHEMBL127546 Bioactive AGN-PC-01LXTN
CFAMM00126061 CHEMBL395998 Bioactive 2-fluoranylethyl 3-[4-[(Z)-2-iodoethenyl]phenyl]-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00126107 DNC012417 Investigative Drug 8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane
CFAMM00125961 DNC013315 Investigative Drug WIN-35065
CFAMM00126032 DNC012406 Investigative Drug 3-p-Tolyl-8-aza-bicyclo[3.2.1]octane
CFAMM00126137 DNC007259 Investigative Drug WIN_35428
CFAMM00125926 DNC007260 Investigative Drug WIN-35066-2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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