CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD110
Family Name Adrenergic neuron Inhibitor guanidine isoquinoline analog Debrisoquin Family
No. of Seeds 2 No. of Other Members 44
Family Centroid CFAMM00022100 Functional Category Approved Drug with Natural Product
Superfamily Adrenergic neuron and Beta adrenergic receptor Binder Superfamily
Class Class 45

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Bethanidine Family 2 22
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
AMP-activated protein kinase Inhibitor Phenformin Family 5 14
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor Sodium... 1 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 10
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (1... 3 0
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00022100 DAP000125 Approved Drug Debrisoquin
CFAMM00022126 DNC012478 Investigative Drug 1,2,3,4-tetrahydroisoquinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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