CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1100
Family Name Tyrosine-protein kinase JAK3 Inhibitor Tofacitinib Family
No. of Seeds 3 No. of Other Members 24
Family Centroid CFAMM00126226 Functional Category Approved Drug
Superfamily Tyrosine-protein kinase JAK3 Inhibitor Tofacitinib Superfamily
Class Class 802

Cousin Family NamesSeedsMembers
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
RAC-alpha serine/threonine-protein kinase inhibitor AGN-PC-07Y... 1 3
Tyrosine-protein kinase JAK3 inhibitor N-methyl-N-[(1S,5S)-2-m... 2 12
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0


External ID

Functional Category

Molecule Name

CFAMM00126226 DNAP001690 Approved Drug Tofacitinib
CFAMM00126222 DCL000092 Clinical Trial Drug CP-690,550
CFAMM00126228 DNC010255 Investigative Drug 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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