CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1104
Family Name Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol Family
No. of Seeds 21 No. of Other Members 79
Family Centroid CFAMM00126292 Functional Category Approved Drug
Superfamily Opioid receptor ligand Tapentadol Superfamily
Class Class 62

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Histamine H1 receptor Ligand Terfenadine Family 3 50
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Oestrogen receptor ligand Dienestrol Family 35 440
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Adenosine receptor A3 and D(2) dopamine receptor Ligand (+)-bu... 5 14
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estrad... 6 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 3 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00126292 DNAP001696 Approved Drug Tapentadol hydrochloride
CFAMM00126368 DNC010450 Investigative Drug Preclamol
CFAMM00126335 DNC010445 Investigative Drug 3-(N-propylpiperidin-4-yl)phenol
CFAMM00126350 DNC008255 Investigative Drug (S)-2-(2-(2-methylpyrrolidin-1-yl)ethyl)phenol
CFAMM00126305 DNC011892 Investigative Drug RTI-5989-25
CFAMM00126328 DNC006152 Investigative Drug O-DESMETHYL TRAMADOL
CFAMM00126283 DPR000068 Investigative Drug LY-25582
CFAMM00126334 DNC012249 Investigative Drug 3-(Octahydro-quinolizin-1-yl)-phenol
CFAMM00126352 DNC008256 Investigative Drug 2-(2-(pyrrolidin-1-yl)ethyl)phenol
CFAMM00126290 DNC012265 Investigative Drug 3-(Octahydro-quinolizin-3-yl)-phenol
CFAMM00126351 DNC008254 Investigative Drug (R)-2-(2-(2-methylpyrrolidin-1-yl)ethyl)phenol
CFAMM00126281 DNC011820 Investigative Drug 3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol
CFAMM00126358 DNC012628 Investigative Drug 3-(2-Methyl-2-aza-bicyclo[3.3.1]non-5-yl)-phenol
CFAMM00126300 DNC012119 Investigative Drug 3-(1-Propyl-pyrrolidin-3-yl)-phenol
CFAMM00126287 DNC012268 Investigative Drug 3-(Octahydro-indolizin-8-yl)-phenol
CFAMM00126337 DNC010443 Investigative Drug 1-Benzyl-4-(3-hydroxyphenyl)piperidine
CFAMM00126296 DNC013581 Investigative Drug MEPTAZINOL
CFAMM00126369 DNC007802 Investigative Drug LY-255582
CFAMM00126345 DNC011786 Investigative Drug 3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol
CFAMM00126286 DNC002657 Investigative Drug 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol
CFAMM00126336 DNC003653 Investigative Drug (+) -3-(1-Propyl-piperidin-3-yl)-phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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