CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD1105
Family Name Citric Acid family
No. of Seeds 2 No. of Other Members 58
Family Centroid CFAMM00126429 Functional Category Approved Drug with Natural Product
Superfamily Citric Acid Superfamily
Class Class 805

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Histamine H1 receptor Ligand Doxylamine Family 2 91
Aromatic-L-amino-acid decarboxylase Inhibitor Vitamin B6 Family 6 13
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Macrophage migration inhibitory factor Inhibitor 4-((pyridin-4... 1 0
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Kappa-type opioid receptor Ligand Clioquinol Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Transient receptor potential cation channel subfamily V member... 1 5
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
Androgen receptor ligand SureCN1990713 family 1 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0
Aromatase inhibitor AGN-PC-075MRV family 1 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 1 0
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00126429 DNAP001697 Approved Drug Citric acid
CFAMM00126399 DNC009337 Investigative Drug 3,3'-Pyridine-2,5-diyldiphenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27047 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543