CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Sodium channel Ligand hydantoin derivative Phenytoin Family
No. of Seeds 2 No. of Other Members 25
Family Centroid CFAMM00022247 Functional Category Approved Drug
Superfamily Sodium channel ligand Hydantoin derivative Phenytoin Mephenytoin Superfamily
Class Class 107

Cousin Family NamesSeedsMembers
Sodium channel protein type 1 subunit alpha Ligand Phenacemide... 5 6
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Beta-secretase 1 Inhibitor 5,5-diphenyl-2-iminohydantoin Family 1 9
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Beta-secretase 1 inhibitor 2-amino-5-[3-(3-chlorophenyl)phenyl... 3 9
Cannabinoid receptor 1 and Fatty-acid amide hydrolase 1 ligand... 2 3
Prolyl endopeptidase inhibitor 3eq9 family 1 0
Cannabinoid receptor 1 ligand 3-butyl-5,5-bis(4-iodophenyl)-2-... 1 1


External ID

Functional Category

Molecule Name

CFAMM00022205 DAP000520 Approved Drug Fosphenytoin
CFAMM00022247 DAP000130 Approved Drug Phenytoin

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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