CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD120
Family Name Cytochrome P450 3A4 Inhibitor Clotrimazole Family
No. of Seeds 16 No. of Other Members 145
Family Centroid CFAMM00022571 Functional Category Approved Drug
Superfamily Cytochrome P450 3A4 Inhibitor Clotrimazole Superfamily
Class Class 113

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
14-alpha sterol demethylase Inhibitor Butoconazole Family 2 53
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Telomerase protein component 1 Inhibitor GRN163L Family 5 29
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor 1-(2-(benzo[b]thiophen-4-yl)ethyl)-1h-imid... 1 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 6 6
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 1 0
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(4-nitrob... 3 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Aromatase Inhibitor 4-imidazol-1-ylmethylthioxanthen-9-one Family 2 4
Aromatase Inhibitor 2-(1h-imidazol-1-yl)-1-(4-nitrophenyl)etha... 2 29
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(3,4-dich... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 6
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Aromatase inhibitor AGN-PC-075MV1 family 1 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Prelamin-A/C inhibitor CHEMBL1611943 family 1 9
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 10 4
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 2
Progesterone receptor and Cytochrome P450 2C19 ligand AGN-PC-0... 8 3
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
5-hydroxytryptamine receptor 2A and Histamine H1 receptor liga... 6 2
Cellular tumor antigen p53 and E3 ubiquitin-protein ligase Mdm... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00022383 DAP000877 Approved Drug Bifonazole
CFAMM00022571 DAP000138 Approved Drug Clotrimazole
CFAMM00022417 CHEMBL1651507 Bioactive 1-Trityl-1H-imidazole
CFAMM00022532 CHEMBL135381 Bioactive SureCN2491523
CFAMM00022563 DNC008639 Investigative Drug 1-(1-Biphenyl-4-yl-butyl)-1H-imidazole
CFAMM00022385 DNC007301 Investigative Drug 1-(9-Phenyl-9H-fluoren-9-yl)1H-imidazole
CFAMM00022569 DNC008633 Investigative Drug 1-(1-(4'-Ethylbiphenyl-4-yl)propyl)-1H-imidazole
CFAMM00022568 DNC008634 Investigative Drug 1-(Bis-biphenyl-4-yl-methyl)-1H-imidazole
CFAMM00022567 DNC008635 Investigative Drug 1-(1-Biphenyl-4-yl-2-phenyl-ethyl)-1H-imidazole
CFAMM00022424 DNC008641 Investigative Drug 1-(1-Biphenyl-4-yl-ethyl)-1H-imidazole
CFAMM00022506 DNC008638 Investigative Drug 1-(1-Biphenyl-4-yl-2-methyl-propyl)-1H-imidazole
CFAMM00022566 DNC008636 Investigative Drug 1-(1-Biphenyl-4-yl-3-methyl-butyl)-1H-imidazole
CFAMM00022423 DNC008640 Investigative Drug 1-(1-Biphenyl-4-yl-propyl)-1H-imidazole
CFAMM00022565 DNC008637 Investigative Drug 1-(1-Biphenyl-4-yl-pentyl)-1H-imidazole
CFAMM00022551 DNC009353 Investigative Drug 1-(1-Benzyl-2-biphenyl-4-yl-ethyl)-1H-imidazole
CFAMM00022570 DNC008631 Investigative Drug 1-(1-(Biphenyl-4-yl)allyl)-1H-imidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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