CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD123
Family Name Voltage-dependent T-type calcium channel subunit alpha-1H ligand piperazine derivative Flunarizine Family
No. of Seeds 10 No. of Other Members 397
Family Centroid CFAMM00022792 Functional Category Approved Drug with Natural Product
Superfamily calcium channel, Histamine H1 receptor, nuclear receptor binding piperazine derivative Flunarizine Cyclizine Meclizine Superfamily
Class Class 115

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Bethanidine Family 2 22
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Beta adrenergic receptor Ligand Bretylium Family 3 11
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Histamine H1 receptor Ligand Antazoline Family 5 57
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Substance-P receptor Ligand Vestipitant Family 14 137
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Bavisant family 9 65
Zicronapine family 43 62
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Sphingosine 1-phosphate receptor 1 Ligand [3-(4-nonyl-benzylam... 9 22
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 7 1
Vesicular acetylcholine transporter inhibitor (3R,4R)-1-[(3-io... 17 20
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
D(1A) dopamine receptor and 5-hydroxytryptamine receptor 2A li... 2 0
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 34
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 6
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
Histamine H3 receptor ligand 2-[4-[4-[2-[(2R)-2-methylpyrrolid... 4 11
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor Sodium... 1 10
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 8 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Substance-P receptor ligand AGN-PC-03NGZZ family 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-4-[(... 3 2
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Histamine H3 receptor ligand SureCN1641166 family 3 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Sigma non-opioid intracellular receptor 1 ligand [(2R)-1,4-dib... 1 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand Sulbentine ... 1 1
Prostaglandin E synthase inhibitor AGN-PC-09QIZR family 1 1
Melanocortin receptor 4 ligand 1-[3-[2-(4-tert-butylphenyl)phe... 1 3
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Pdk3 protein and [Pyruvate dehydrogenase (acetyl-transferring)... 3 0
Melanocortin receptor 4 ligand 1-[4-(2-bromonaphthalen-1-yl)bu... 1 2
Retinal dehydrogenase 1 and Muscleblind-like protein 1 inhibit... 1 0
Acetylcholinesterase inhibitor (E)-1-N'-benzyl-1-N-[2-(1-benzy... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (1... 3 0
1-benzyl-3,6-diazatricyclo[4.3.1.1~3,8~]undecan-9-amine NP ZIN... 2 1
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00022836 DAP000325 Approved Drug Cinnarizine
CFAMM00022792 DAP000142 Approved Drug Flunarizine
CFAMM00022664 CHEMBL162522 Bioactive 1,4-Dibenzylpiperazine
CFAMM00022697 CHEMBL320801 Bioactive 1-benzyl-N,N-bis[(E)-3-phenylprop-2-enyl]piperidin-4-amine;(E)-but-2-enedioic acid
CFAMM00022747 CHEMBL273041 Bioactive 1-benzyl-4-(3-phenylpropyl)piperazine
CFAMM00022716 DNC005844 Investigative Drug 1-Methyl-4-(1-phenyl-ethyl)-piperazine
CFAMM00022983 DNC014270 Investigative Drug 1-benzhydryl-4-(3,3-diphenylpropyl)piperazine
CFAMM00022827 DNC006804 Investigative Drug 1-(1,3-diphenylpropyl)piperazine
CFAMM00022688 DNC006815 Investigative Drug 1-(1,2-diphenylethyl)piperazine
CFAMM00022984 DNC014271 Investigative Drug 1-benzhydryl-4-(4,4-diphenylbutyl)piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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