CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD130
Family Name CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrinone Family
No. of Seeds 3 No. of Other Members 55
Family Centroid CFAMM00023307 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrinone Superfamily
Class Class 11

Cousin Family NamesSeedsMembers
Enoyl-[acyl-carrier-protein] reductase [NADH] inhibitor pyridi... 3 24
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Cyclin-dependent kinase 8 Inhibitor Oxindole 94 Family 2 3
Aromatase Inhibitor Rogletimide Family 1 2
Platelet-derived growth factor receptor alpha and Platelet-der... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Histamine H3 receptor ligand SureCN1857507 family 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Acetylcholinesterase and Cholinesterase inhibitor 1-pyridin-4-... 1 1
Survival motor neuron protein and Microtubule-associated prote... 1 0
DNA polymerase beta inhibitor AE-406/41056622 family 1 1
DNA gyrase subunit A and DNA gyrase subunit B inhibitor AGN-PC... 2 0
D-amino-acid oxidase inhibitor naphthyridinone analog.,21 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00023324 DAP000150 Approved Drug Milrinone
CFAMM00023307 DAP000610 Approved Drug Amrinone
CFAMM00023264 DNC004106 Investigative Drug 3-Pyridin-4-yl-quinolin-7-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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