Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Enoyl-[acyl-carrier-protein] reductase [NADH] inhibitor pyridi... 3 24 Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686 Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243 Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352 Histamine H1 receptor Ligand Triprolidine Family 19 316 Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68 26S proteasome Inhibitor Bortezomib Family 7 65 SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85 Prothrombin Inhibitor Ximelegatran Family 8 157 Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154 Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24 Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118 D(3) dopamine receptor Ligand SB-277011 Family 13 178 Substance-P receptor Ligand TAK-637 Family 18 63 Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13 C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106 cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34 Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7 Cyclin-dependent kinase 8 Inhibitor Oxindole 94 Family 2 3 Aromatase Inhibitor Rogletimide Family 1 2 Platelet-derived growth factor receptor alpha and Platelet-der... 2 1 cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40 Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22 Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26 Transient receptor potential cation channel subfamily V member... 6 23 D(4) dopamine receptor Ligand ABT-670 Family 4 14 Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10 Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14 Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11 Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4 Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19 Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46 Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0 Disintegrin and metalloproteinase domain-containing protein 17... 3 3 Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3 Histamine H3 receptor ligand SureCN1857507 family 1 4 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4 Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5 Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2 Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3 Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1 Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2 Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4 Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15 Platelet-activating factor receptor ligand SureCN9853140 family 3 3 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1 Acetylcholinesterase and Cholinesterase inhibitor 1-pyridin-4-... 1 1 Survival motor neuron protein and Microtubule-associated prote... 1 0 DNA polymerase beta inhibitor AE-406/41056622 family 1 1 DNA gyrase subunit A and DNA gyrase subunit B inhibitor AGN-PC... 2 0 D-amino-acid oxidase inhibitor naphthyridinone analog.,21 family 2 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00023268 CHEMBL99111 Bioactive
(2S)-2-amino-1-piperidin-1-yl-4-(pyridin-4-ylmethylamino)butan-1-one CFAMM00023271 CHEMBL51696 Bioactive
(2Z)-5,5-diphenyl-N-(4-pyridin-3-ylbutyl)penta-2,4-dienamide CFAMM00023313 CHEMBL241960 Bioactive
AGN-PC-046EVM CFAMM00023279 CHEMBL300463 Bioactive
(2E)-5-pentyl-N-[(2R)-5-pyridin-3-ylpentan-2-yl]deca-2,4-dienamide CFAMM00023263 CHEMBL2179525 Bioactive
3,6-diazabicyclo[3.2.1]octan-3-yl(pyridin-4-yl)methanone CFAMM00023274 CHEMBL574646 Bioactive
(3E,5E)-3,5-bis(pyridin-2-ylmethylidene)piperidin-4-one CFAMM00023277 HMDB35170 Human Metabolite
1',2'-Dihydro-1,1'-dimethyl-2'-oxo-4,4'-bipyridinium(1+) CFAMM00023287 DNC004078 Investigative Drug
3-Pyridin-4-yl-quinoline-6,7-diol CFAMM00023275 DNC010796 Investigative Drug
4-(6-phenyl-2,4'-bipyridin-4-yl)phenol CFAMM00023285 ZINC00128001 Natural Product
6-oxo-1,6-dihydro-[2,3'-bipyridine]-5-carbonitrile CFAMM00023282 321320 Patent Compound
N-2-Picolylbenzamide CFAMM00023299 54033227 Patent Compound
CFAMM00023317 20514967 Patent Compound
SureCN11238459 CFAMM00023333 23339786 Patent Compound
SureCN11448149 CFAMM00023288 14209093 Patent Compound
SureCN10664526 CFAMM00023273 11971510 Patent Compound
2-Ethyl-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one CFAMM00023308 20506519 Patent Compound
AGN-PC-02UON2 CFAMM00023323 21266437 Patent Compound
SureCN4676050 CFAMM00023280 20523870 Patent Compound
CFAMM00023265 19037333 Patent Compound
AGN-PC-025Q44 CFAMM00023297 17903521 Patent Compound
SureCN3854866 CFAMM00023316 54076063 Patent Compound
SureCN7347683 CFAMM00023332 12668477 Patent Compound
SureCN7220004 CFAMM00023272 54096381 Patent Compound
CFAMM00023322 20470825 Patent Compound
SureCN11083179 CFAMM00023295 20515031 Patent Compound
SureCN11236260 CFAMM00023315 20212813 Patent Compound
SureCN10807931 CFAMM00023329 23339843 Patent Compound
AGN-PC-041LUJ CFAMM00023286 54286040 Patent Compound
SureCN11249495 CFAMM00023306 20514943 Patent Compound
SureCN11238085 CFAMM00023321 14950467 Patent Compound
SureCN9136486 CFAMM00023278 20514911 Patent Compound
AGN-PC-02USXX CFAMM00023294 20514987 Patent Compound
SureCN11242290 CFAMM00023327 23339814 Patent Compound
CFAMM00023270 57017799 Patent Compound
AGN-PC-0BKRQW CFAMM00023305 56981941 Patent Compound
CFAMM00023320 20527854 Patent Compound
AGN-PC-02UZZI CFAMM00023262 20400760 Patent Compound
SureCN7340324 CFAMM00023292 19775530 Patent Compound
AGN-PC-02JWVA CFAMM00023311 20527795 Patent Compound
AGN-PC-02UZY4 CFAMM00023326 20515009 Patent Compound
SureCN11243997 CFAMM00023269 20351348 Patent Compound
AGN-PC-02RZA8 CFAMM00023284 20523891 Patent Compound
CFAMM00023303 54297648 Patent Compound
AGN-PC-0A5GF4 CFAMM00023319 15294776 Patent Compound
SureCN7384727 CFAMM00023290 20447568 Patent Compound
SureCN10912596 CFAMM00023261 20553030 Patent Compound
CFAMM00023310 687032 Patent Compound
N-benzylpyridine-2-carboxamide CFAMM00023325 12799339 Patent Compound
SureCN11236528 CFAMM00023283 23040478 Patent Compound
AGN-PC-03YCQX CFAMM00023302 255093 Patent Compound
n-[2-(pyridin-4-yl)ethyl]acetamide CFAMM00023318 22124621 Patent Compound
AGN-PC-03KQOW CFAMM00023289 21293895 Patent Compound
SureCN10668256 CFAMM00023309 13891223 Patent Compound
SureCN7325083 CFAMM00023267 53663438 Patent Compound
AGN-PC-00NFXX
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
