Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members Enoyl-[acyl-carrier-protein] reductase [NADH] inhibitor pyridi... 3 24 Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686 Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243 Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352 Histamine H1 receptor Ligand Triprolidine Family 19 316 Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68 26S proteasome Inhibitor Bortezomib Family 7 65 SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85 Prothrombin Inhibitor Ximelegatran Family 8 157 Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154 Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24 Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118 D(3) dopamine receptor Ligand SB-277011 Family 13 178 Substance-P receptor Ligand TAK-637 Family 18 63 Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13 C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106 cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34 Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7 Cyclin-dependent kinase 8 Inhibitor Oxindole 94 Family 2 3 Aromatase Inhibitor Rogletimide Family 1 2 Platelet-derived growth factor receptor alpha and Platelet-der... 2 1 cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40 Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22 Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26 Transient receptor potential cation channel subfamily V member... 6 23 D(4) dopamine receptor Ligand ABT-670 Family 4 14 Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10 Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14 Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11 Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4 Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19 Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46 Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0 Disintegrin and metalloproteinase domain-containing protein 17... 3 3 Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3 Histamine H3 receptor ligand SureCN1857507 family 1 4 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4 Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5 Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2 Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3 Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1 Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2 Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4 Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15 Platelet-activating factor receptor ligand SureCN9853140 family 3 3 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1 Acetylcholinesterase and Cholinesterase inhibitor 1-pyridin-4-... 1 1 Survival motor neuron protein and Microtubule-associated prote... 1 0 DNA polymerase beta inhibitor AE-406/41056622 family 1 1 DNA gyrase subunit A and DNA gyrase subunit B inhibitor AGN-PC... 2 0 D-amino-acid oxidase inhibitor naphthyridinone analog.,21 family 2 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00023268
CHEMBL99111
Bioactive
(2S)-2-amino-1-piperidin-1-yl-4-(pyridin-4-ylmethylamino)butan-1-one CFAMM00023271
CHEMBL51696
Bioactive
(2Z)-5,5-diphenyl-N-(4-pyridin-3-ylbutyl)penta-2,4-dienamide CFAMM00023313
CHEMBL241960
Bioactive
AGN-PC-046EVM CFAMM00023274
CHEMBL574646
Bioactive
(3E,5E)-3,5-bis(pyridin-2-ylmethylidene)piperidin-4-one CFAMM00023279
CHEMBL300463
Bioactive
(2E)-5-pentyl-N-[(2R)-5-pyridin-3-ylpentan-2-yl]deca-2,4-dienamide CFAMM00023263
CHEMBL2179525
Bioactive
3,6-diazabicyclo[3.2.1]octan-3-yl(pyridin-4-yl)methanone CFAMM00023277
HMDB35170
Human Metabolite
1',2'-Dihydro-1,1'-dimethyl-2'-oxo-4,4'-bipyridinium(1+) CFAMM00023275
DNC010796
Investigative Drug
4-(6-phenyl-2,4'-bipyridin-4-yl)phenol CFAMM00023287
DNC004078
Investigative Drug
3-Pyridin-4-yl-quinoline-6,7-diol CFAMM00023285
ZINC00128001
Natural Product
6-oxo-1,6-dihydro-[2,3'-bipyridine]-5-carbonitrile CFAMM00023320
20527854
Patent Compound
AGN-PC-02UZZI CFAMM00023262
20400760
Patent Compound
SureCN7340324 CFAMM00023292
19775530
Patent Compound
AGN-PC-02JWVA CFAMM00023311
20527795
Patent Compound
AGN-PC-02UZY4 CFAMM00023326
20515009
Patent Compound
SureCN11243997 CFAMM00023269
20351348
Patent Compound
AGN-PC-02RZA8 CFAMM00023284
20523891
Patent Compound
CFAMM00023303
54297648
Patent Compound
AGN-PC-0A5GF4 CFAMM00023319
15294776
Patent Compound
SureCN7384727 CFAMM00023290
20447568
Patent Compound
SureCN10912596 CFAMM00023261
20553030
Patent Compound
CFAMM00023310
687032
Patent Compound
N-benzylpyridine-2-carboxamide CFAMM00023325
12799339
Patent Compound
SureCN11236528 CFAMM00023283
23040478
Patent Compound
AGN-PC-03YCQX CFAMM00023302
255093
Patent Compound
n-[2-(pyridin-4-yl)ethyl]acetamide CFAMM00023318
22124621
Patent Compound
AGN-PC-03KQOW CFAMM00023289
21293895
Patent Compound
SureCN10668256 CFAMM00023309
13891223
Patent Compound
SureCN7325083 CFAMM00023267
53663438
Patent Compound
AGN-PC-00NFXX CFAMM00023282
321320
Patent Compound
N-2-Picolylbenzamide CFAMM00023299
54033227
Patent Compound
CFAMM00023317
20514967
Patent Compound
SureCN11238459 CFAMM00023333
23339786
Patent Compound
SureCN11448149 CFAMM00023273
11971510
Patent Compound
2-Ethyl-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one CFAMM00023288
14209093
Patent Compound
SureCN10664526 CFAMM00023308
20506519
Patent Compound
AGN-PC-02UON2 CFAMM00023323
21266437
Patent Compound
SureCN4676050 CFAMM00023265
19037333
Patent Compound
AGN-PC-025Q44 CFAMM00023280
20523870
Patent Compound
CFAMM00023297
17903521
Patent Compound
SureCN3854866 CFAMM00023316
54076063
Patent Compound
SureCN7347683 CFAMM00023332
12668477
Patent Compound
SureCN7220004 CFAMM00023272
54096381
Patent Compound
CFAMM00023322
20470825
Patent Compound
SureCN11083179 CFAMM00023295
20515031
Patent Compound
SureCN11236260 CFAMM00023315
20212813
Patent Compound
SureCN10807931 CFAMM00023329
23339843
Patent Compound
AGN-PC-041LUJ CFAMM00023286
54286040
Patent Compound
SureCN11249495 CFAMM00023306
20514943
Patent Compound
SureCN11238085 CFAMM00023321
14950467
Patent Compound
SureCN9136486 CFAMM00023278
20514911
Patent Compound
AGN-PC-02USXX CFAMM00023294
20514987
Patent Compound
SureCN11242290 CFAMM00023270
57017799
Patent Compound
AGN-PC-0BKRQW CFAMM00023327
23339814
Patent Compound
CFAMM00023305
56981941
Patent Compound
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
25238 visits since 2014 .........
Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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