CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD131
Family Name Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family
No. of Seeds 7 No. of Other Members 421
Family Centroid CFAMM00023783 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Prostaglandin G/H synthase inhibitor salicylates and derivatives Superfamily
Class Class 121

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Retinoid X receptor Ligand Bexarotene Family 7 492
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand Dienestrol Family 35 440
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Danthron family 11 141
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Substance-P receptor Ligand CI-1021 Family 1 0
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Apoptosis regulator Bcl-2 Inhibitor Gossypol Family 1 9
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU78299 F... 2 1
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
DNA topoisomerase 2-beta Inhibitor Demethylzeylasterone Family 1 2
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Indoleamine 2,3-dioxygenase 1 Inhibitor Garveatin E Family 2 0
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-622444 Family 2 18
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Isocitrate lyase Inhibitor Bis(3-bromo-4,5-dihydroxyphenyl)met... 1 2
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Cholinesterase inhibitor [(3R,3aR,6S,6aR)-6-(ethylcarbamoyloxy... 2 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 2
Reverse transcriptase/RNaseH inhibitor AC1L9WPU family 1 1
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-benzyl-3,17-... 1 1
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Nuclear receptor ROR-gamma and Huntingtin ligand CHEMBL1568747... 1 3
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 2
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Catechol O-methyltransferase inhibitor 4,5-dihydroxybenzene-1,... 1 1
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
5-lipoxygenase inhibitor 6-(1,8-dihydroxy-9-oxo-10H-anthracen-... 6 0
Benzofurans Metabolite 4-Hydroxyphthalide Family 1 1
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Acenes Metabolite Lacinilene C Family 2 3
Acenes Metabolite 3-Hydroxy-9-(4-hydroxyphenyl)-1H,3H-naphtho[... 1 0
Putative NP ZINC49600254 Family 8 2
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
2-[(E)-3-hydroxy-3-(6-methyl-2,4-dioxopyran-3-ylidene)prop-1-e... 1 0
Putative NP ZINC04898806 Family 3 2
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00023783 DAP000152 Approved Drug Diflunisal
CFAMM00023642 DNC003072 Investigative Drug 3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID
CFAMM00023571 DNC013706 Investigative Drug 2'-Hydroxychalcone
CFAMM00023852 DNC014852 Investigative Drug (2-hydroxyphenyl)(4-hydroxyphenyl)methanone
CFAMM00023628 DNC006777 Investigative Drug NSC-622445
CFAMM00023617 DNC010375 Investigative Drug NSC-623548
CFAMM00023485 DNC009416 Investigative Drug 3-Bromo-5-phenylsalicylc acid

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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