CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Serine/threonine-protein kinase mTOR and Serine/threonine-protein kinase mTOR inhibitor macrolide Sirolimus Family
No. of Seeds 14 No. of Other Members 34
Family Centroid CFAMM00024732 Functional Category Approved Drug with Human Metabolite
Superfamily Serine/threonine-protein kinase inhibitor macrolide,Calcineurin inhibitor macrolactam Superfamily
Class Class 128

Cousin Family NamesSeedsMembers
Calcineurin inhibitor macrolactam Pimecrolimus Family 24 1


External ID

Functional Category

Molecule Name

CFAMM00024732 DAP000663 Approved Drug Sirolimus
CFAMM00024785 DAP001222 Approved Drug Temsirolimus
CFAMM00024737 DNAP001300 Approved Drug Biolimus a9
CFAMM00024750 DAP000162 Approved Drug Tacrolimus
CFAMM00024784 DAP001223 Approved Drug Everolimus
CFAMM00024763 CHEMBL140442 Bioactive CHEMBL140442
CFAMM00024753 CHEMBL269553 Bioactive CHEMBL269553
CFAMM00024775 CHEMBL295272 Bioactive rapamycin
CFAMM00024731 DCL001094 Clinical Trial Drug AP23573
CFAMM00024751 DCL000624 Clinical Trial Drug Ridaforolimus
CFAMM00024759 DCL000767 Clinical Trial Drug Deforolimus
CFAMM00024734 DCL000469 Clinical Trial Drug AZD4818
CFAMM00024733 DNC002706 Investigative Drug Rapamycin Immunosuppressant Drug
CFAMM00024777 DNC000934 Investigative Drug Methoxyestradiol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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