CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Calcineurin Inhibitor Cyclosporine Family
No. of Seeds 15 No. of Other Members 52
Family Centroid CFAMM00002527 Functional Category Approved Drug
Superfamily Calcineurin Inhibitor Cyclosporine Superfamily
Class Class 14


External ID

Functional Category

Molecule Name

CFAMM00002527 DAP000014 Approved Drug Cyclosporine
CFAMM00002506 CHEMBL2375162 Bioactive (3S,6S,9S,12R,15S,18S,21S,24S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-24-[(2S)-2-methylbutyl]-6,9,18-tris(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
CFAMM00002469 CHEMBL2407581 Bioactive AC1O57JM
CFAMM00002540 CHEMBL1688529 Bioactive NIM811
CFAMM00002514 CHEMBL1213341 Bioactive SCY-635
CFAMM00002531 CHEMBL384718 Bioactive (3S,6S,9R,12R,15S,18S,21R,24R,30S,33S)-30-ethyl-33-[(E,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
CFAMM00002497 CHEMBL3038087 Bioactive AC1O57JG
CFAMM00002547 CHEMBL160 Bioactive cyclosporin A
CFAMM00002546 CHEMBL216520 Bioactive (3R,6S,8S,9R,14S,15S,17S,20R,27R,29S,30S,32S,33S)-21-ethyl-8,14,17,20,29,32-hexahydroxy-24-[(E)-1-hydroxy-2-methylhex-4-enyl]-1,3,6,10,16,19,25,28,31-nonamethyl-9,15,30,33-tetrakis(2-methylpropyl)-12,27-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,11,23,26-pentone
CFAMM00002509 DCL001238 Clinical Trial Drug SCY-635
CFAMM00002521 DCL000762 Clinical Trial Drug Cyclosporin A
CFAMM00002512 DCL001177 Clinical Trial Drug Debio 025
CFAMM00002510 DCL001037 Clinical Trial Drug Voclosporin
CFAMM00002541 DNC012149 Investigative Drug [(40-OH)MeLeu]4-Cyclosporin A
CFAMM00002473 DNC012164 Investigative Drug [(D)MeSer]3-[(40-OH) MeLeu]4-Cyclosporin A

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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