CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD142
Family Name Glutamate dehydrogenase inhibitor quinoline derivative Chloroquine Family
No. of Seeds 7 No. of Other Members 189
Family Centroid CFAMM00024816 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Glutamate dehydrogenase, calcium ATPase binding quinoline derivative Chloroquine Piperaquine Superfamily
Class Class 131

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Amg 423 family 7 47
ABC294640 family 5 75
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Transient receptor potential cation channel subfamily V member... 3 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 2
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Neuropeptide Y receptor type 5 ligand 2-(6-chloroindol-1-yl)-N... 4 23
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 11 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Cannabinoid receptor 1 ligand N-[[(3R,6S)-1-(4-chlorophenyl)-6... 2 0
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (2Z)-... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00024816 DAP000165 Approved Drug Chloroquine
CFAMM00024815 DAP000878 Approved Drug Hydroxychloroquine
CFAMM00025002 CHEMBL356811 Bioactive 7-chloro-N-[3-[4-[3-(dibutylamino)propyl]piperazin-1-yl]propyl]quinolin-4-amine
CFAMM00024921 CHEMBL15289 Bioactive AGN-PC-00GXCU
CFAMM00024949 CHEMBL15101 Bioactive 7-chloro-N-(7-piperidin-1-ylheptyl)quinolin-4-amine
CFAMM00024875 CHEMBL250447 Bioactive CHEBI:39254
CFAMM00024873 DNCL003746 Clinical Trial Drug Ferroquine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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