CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD145
Family Name HIV protease Inhibitor Indinavir Family
No. of Seeds 36 No. of Other Members 211
Family Centroid CFAMM00025133 Functional Category Approved Drug with Natural Product
Superfamily HIV protease Inhibitor Indinavir Superfamily
Class Class 134

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor ligand ergot alkaloid Dihydroergota... 7 12
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Substance-P receptor Ligand GSK424887 Family 8 184
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Coagulation factor X Inhibitor Otamixaban Family 9 21
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
CP-18770 family 6 27
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Renin Inhibitor Enalkiren Family 56 44
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Chymase Inhibitor NK3201 Family 1 0
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
Plasmepsin-2 Inhibitor KNI-10526 Family 8 10
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Renin and Pepsin A inhibitor [(2S)-1-[[(2R)-1-[[(2S,3R)-1-cycl... 2 2
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Pol polyprotein inhibitor BEJ family 2 0
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Pol polyprotein inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-... 7 3
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 3 0
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Pol polyprotein inhibitor AC1LAHRX family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2R)-2... 1 0
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(butyl... 2 4
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Pol polyprotein inhibitor 183854-98-0 family 15 2
Pol polyprotein inhibitor Cyclic Urea 68 family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Pol polyprotein inhibitor AC1LALGZ family 2 14
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Growth factor receptor-bound protein 2 ligand 2-[4-[(2S)-3-[[1... 1 0
Pol polyprotein inhibitor 183854-15-1 family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Pol polyprotein inhibitor [(2R,3R)-1,1-dioxo-2-propan-2-ylthio... 11 0
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Pol polyprotein inhibitor (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 1 0
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347784 family 4 0
Renin inhibitor SureCN7300793 family 2 5
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 1 0
Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 7 4
Prothrombin inhibitor N-[(1S)-2-[4-(2-fluoroethyl)piperidin-1-... 5 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 0
Prothrombin inhibitor 2-[(3S)-4-[4-(2-fluoroethyl)piperidin-1-... 1 0
Pol polyprotein inhibitor AC1LA6OV family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00025133 DAP000168 Approved Drug Indinavir
CFAMM00025062 CHEMBL322214 Bioactive tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-1-phenyl-5-(pyridin-4-ylmethyl)hexan-2-yl]carbamate
CFAMM00025282 CHEMBL421568 Bioactive AC1LAIKF
CFAMM00025075 CHEMBL325267 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-[(6-ethoxypyridin-3-yl)methyl]piperazine-2-carboxamide
CFAMM00025148 CHEMBL325885 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-pyridin-3-ylsulfonylpiperazine-2-carboxamide
CFAMM00025205 CHEMBL316454 Bioactive AC1LAIKL
CFAMM00025061 CHEMBL47610 Bioactive AC1L9R9E
CFAMM00025134 CHEMBL324916 Bioactive (2R)-N-[(2S,3S,4R,5S)-3,4-dihydroxy-5-[[(2S)-3-methyl-2-(3-pyridin-3-ylpropanoylamino)butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-(3-pyridin-3-ylpropanoylamino)butanamide
CFAMM00025101 CHEMBL361683 Bioactive (2R,4S)-2-benzyl-5-[(5R)-5-benzyl-2-oxo-3-(pyridin-3-ylmethyl)pyrrolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00025153 CHEMBL430692 Bioactive tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-6-oxo-1-phenyl-5-(pyridin-4-ylmethyl)hexan-2-yl]carbamate
CFAMM00025280 CHEMBL317926 Bioactive AC1LAIK0
CFAMM00025260 CHEMBL96100 Bioactive AC1LAIKU
CFAMM00025225 CHEMBL318525 Bioactive AC1LAIK9
CFAMM00025139 CHEMBL96697 Bioactive AC1LAIKO
CFAMM00025079 CHEMBL186704 Bioactive (2R,4S)-2-benzyl-5-[(5R)-5-benzyl-2-oxo-3-(pyridin-4-ylmethyl)pyrrolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00025049 CHEMBL320665 Bioactive (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[[(2S)-1-[4-(methoxymethoxy)piperidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]hexanoyl]amino]-2-propan-2-yl-N-(pyridin-4-ylmethyl)hexanamide
CFAMM00025266 CHEMBL112257 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-[(2-methylsulfanylpyridin-3-yl)methyl]piperazine-2-carboxamide
CFAMM00025279 CHEMBL325395 Bioactive AGN-PC-074YXM
CFAMM00025085 CHEMBL1735 Bioactive Indinavir sulfate
CFAMM00025231 CHEMBL116107 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-[(6-chloropyridin-3-yl)methyl]piperazine-2-carboxamide
CFAMM00025041 CHEMBL333607 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-[(6-methylpyridin-3-yl)methyl]piperazine-2-carboxamide
CFAMM00025216 CHEMBL326337 Bioactive AGN-PC-074YP5
CFAMM00025084 CHEMBL313876 Bioactive (2S)-N-tert-butyl-1-[(2S,4R)-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxo-4-(pyridin-4-ylmethyl)pentyl]-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide
CFAMM00025098 CHEMBL325946 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(2,3-dihydrofuro[2,3-b]pyridin-5-ylmethyl)piperazine-2-carboxamide
CFAMM00025124 CHEMBL325951 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(quinolin-3-ylmethyl)piperazine-2-carboxamide
CFAMM00025174 CHEMBL311979 Bioactive AC1LAX1B
CFAMM00025236 CHEMBL323882 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-[(2-methoxypyridin-3-yl)methyl]piperazine-2-carboxamide
CFAMM00025187 CHEMBL116954 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-quinolin-8-ylsulfonylpiperazine-2-carboxamide
CFAMM00025201 CHEMBL319053 Bioactive AC1LAIKC
CFAMM00025264 CHEMBL96796 Bioactive (2R)-4-(4-aminopiperidin-1-yl)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-1-oxopentan-2-yl]-4-oxobutanamide
CFAMM00025283 CHEMBL96645 Bioactive AC1LAIKR
CFAMM00025160 CHEMBL151824 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-[(1-methylindol-3-yl)methyl]piperazine-2-carboxamide
CFAMM00025200 CHEMBL113845 Bioactive AGN-PC-074YTH
CFAMM00025116 CHEMBL96352 Bioactive (2S)-N-tert-butyl-1-[(2S,4R)-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxo-4-(pyridin-3-ylmethyl)pentyl]-4-quinolin-8-ylsulfonylpiperazine-2-carboxamide
CFAMM00025082 CHEMBL103463 Bioactive (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[[(2S)-1-[4-(methoxymethoxy)piperidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]hexanoyl]amino]-2-propan-2-yl-N-(pyridin-3-ylmethyl)hexanamide
CFAMM00025122 CHEMBL113826 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-4-ylmethyl)piperazine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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