CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD146
Family Name HIV protease Inhibitor Ritonavir Family
No. of Seeds 12 No. of Other Members 49
Family Centroid CFAMM00025332 Functional Category Approved Drug
Superfamily HIV protease Inhibitor Ritonavir Superfamily
Class Class 135

Cousin Family NamesSeedsMembers
Renin Inhibitor Zankiren Family 32 50
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 1 1
Cruzipain and Cathepsin L1 inhibitor pyridin-3-ylmethyl N-[(2S... 7 4
Histone deacetylase 2 and Histone deacetylase 1 inhibitor benz... 1 10
Pol polyprotein inhibitor (2S)-N-[(2S,3S,4S,5S)-5-[[(2R)-2-[[(... 2 1
Cytochrome P450 3A4 inhibitor 1,3-thiazol-5-ylmethyl N-[(2S)-1... 2 2
Cytochrome P450 3A4 inhibitor 1,3-thiazol-5-ylmethyl N-[(2S)-1... 1 0
Cytochrome P450 3A4 inhibitor 1,3-thiazol-5-ylmethyl N-[(2S)-1... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00025332 DAP000169 Approved Drug Ritonavir
CFAMM00025344 CHEMBL346943 Bioactive (4-propan-2-yl-1,3-thiazol-2-yl)methyl N-[1-[[(2S,3S,5S)-3-hydroxy-1,6-diphenyl-5-(1,3-thiazol-5-ylmethoxycarbonylamino)hexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00025310 CHEMBL154831 Bioactive AC1LALBZ
CFAMM00025352 CHEMBL347802 Bioactive AC1LALBN
CFAMM00025329 CHEMBL351145 Bioactive (2-propan-2-yl-1,3-thiazol-5-yl)methyl N-[(2S,4S,5S)-4-hydroxy-5-[[3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
CFAMM00025309 CHEMBL155636 Bioactive AC1LALC2
CFAMM00025328 CHEMBL155588 Bioactive 1,3-thiazol-5-ylmethyl N-[(2S,4S,5S)-5-[2-[[cyclopropyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]propanoylamino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate
CFAMM00025308 CHEMBL348147 Bioactive 1,3-thiazol-5-ylmethyl N-[(2S,4S,5S)-5-[[2-[[cyclopropyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-3-methylbutanoyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate
CFAMM00025355 CHEMBL347824 Bioactive 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-5-[2-[[ethyl-[2-(2-propan-2-yl-1,3-thiazol-4-yl)ethyl]carbamoyl]amino]propanoylamino]-3-hydroxy-1,6-diphenylhexan-2-yl]carbamate
CFAMM00025339 CHEMBL346120 Bioactive AC1LALBK
CFAMM00025338 CHEMBL157673 Bioactive 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-1,6-diphenyl-5-[2-[[2-(2-propan-2-yl-1,3-thiazol-4-yl)ethyl-propylcarbamoyl]amino]propanoylamino]hexan-2-yl]carbamate
CFAMM00025347 DNCL002983 Clinical Trial Drug Cobicistat

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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