CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name HIV protease Inhibitor Amprenavir Family
No. of Seeds 7 No. of Other Members 15
Family Centroid CFAMM00025389 Functional Category Approved Drug
Superfamily HIV protease Inhibitor Amprenavir Superfamily
Class Class 136

Cousin Family NamesSeedsMembers
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Pol polyprotein inhibitor Lysine Sulfonamide 14a family 12 3
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 0
Pol polyprotein inhibitor AC1LAHQ3 family 13 0
Pol polyprotein and Pepsin A-5 inhibitor Lysine derivative 28 ... 2 10
Pol polyprotein inhibitor SureCN4637317 family 19 6
Pol polyprotein inhibitor SureCN4782454 family 5 3


External ID

Functional Category

Molecule Name

CFAMM00025366 DAP000707 Approved Drug Fosamprenavir
CFAMM00025376 DAP001086 Approved Drug Darunavir
CFAMM00025389 DAP000170 Approved Drug Amprenavir
CFAMM00025362 CHEMBL435733 Bioactive arylsulfonamide 11a
CFAMM00025386 CHEMBL350301 Bioactive AC1LAPOF
CFAMM00025374 CHEMBL213012 Bioactive [(3aS,5R,6aR)-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]furan-5-yl] N-[4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00025363 CHEMBL195725 Bioactive AC1L1D3F

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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