CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD152
Family Name Nicotinic acetylcholine receptor Ligand Nicotine Family
No. of Seeds 14 No. of Other Members 686
Family Centroid CFAMM00026116 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Histamine H1 receptor ligand Pheniramine Triprolidine, Nicotinic acetylcholine receptor ligand Nicotine Superfamily
Class Class 141

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Farnesyl pyrophosphate synthase Inhibitor Risedronate Family 4 28
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Substance-P receptor Ligand TAK-637 Family 18 63
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Amg 423 family 7 47
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Class II cytokine receptor Ligand IL-10 Family 7 45
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Peptide deformylase, mitochondrial Inhibitor Hydroxy[3-(6-meth... 1 0
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Aromatase Inhibitor Rogletimide Family 1 2
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor Cycl... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... 7 2
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Fatty-acid amide hydrolase 1 Inhibitor 6-fluoropyridin-3-ylbor... 1 2
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Tyrosinase Inhibitor 5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3h)-... 1 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5
Metabotropic glutamate receptor 5 ligand [18F]FDEGPECO family 5 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-(3-pyri... 1 6
S-adenosylmethionine decarboxylase proenzyme inhibitor 6-[(E)-... 2 6
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Histamine H3 receptor ligand SureCN1857507 family 1 4
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 2
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 0
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 0
D(3) dopamine receptor and D(4) dopamine receptor ligand (7S)-... 1 2
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 2 0
5-hydroxytryptamine receptor 7 ligand 6-bromo-1-[2-[4-(cyclopr... 2 4
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Nuclear receptor ROR-gamma and Prelamin-A/C ligand 13463-41-7 ... 1 7
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Adenosine receptor A3 and Adenosine receptor A1 ligand 1,3-dim... 1 2
Acetylcholine-binding protein and Neuronal acetylcholine recep... 1 5
NADPH oxidase 4 inhibitor AGN-PC-09M5SP family 1 1
Survival motor neuron protein and Microtubule-associated prote... 1 0
Tyrosyl-DNA phosphodiesterase 1 and Inositol monophosphatase 1... 1 3
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 1 5
Neutrophil elastase and Chymotrypsin-like elastase family memb... 2 1
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
NP 3-((1-(3-(2-(pyridin-3-yl)piperidin-1-yl)prop-1-yn-1-yl)cyc... 12 0
N-[2-(1-oxidopyridin-1-ium-2-yl)ethyl]-N-phenylacetamide NP 2-... 1 2
Putative NP ZINC38570085 Family 14 0
Putative NP ZINC19701930 Family 2 2
1,5-dioxidopyrrolo[3,2-c]pyridin-5-ium NP Agn-pc-0639xa Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00026116 DAP000175 Approved Drug Nicotine
CFAMM00026771 DNAP001675 Approved Drug Cotinine
CFAMM00026575 CHEMBL440464 Bioactive 3-(1-methylpyrrolidin-2-yl)pyridine
CFAMM00026466 CHEMBL664 Bioactive 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
CFAMM00026583 CHEMBL294757 Bioactive (+/-)-6-METHYLNICOTINE
CFAMM00026738 CHEMBL72470 Bioactive SureCN2615463
CFAMM00026057 CHEMBL225057 Bioactive Nicotine HCl
CFAMM00026783 CHEMBL9732 Bioactive D-Nicotine
CFAMM00026737 CHEMBL432837 Bioactive SureCN10886848
CFAMM00026813 CHEMBL103225 Bioactive AGN-PC-000GYN
CFAMM00026146 CHEMBL365343 Bioactive CHEBI:681857
CFAMM00026157 CHEMBL55606 Bioactive 1-dodecyl-3-[(2S)-1-methylpyrrolidin-2-yl]pyridin-1-ium;iodide
CFAMM00026112 CHEMBL1628647 Bioactive [3H]NICOTINE
CFAMM00026544 DNC008265 Investigative Drug (R)-3-(2-(2-methylpyrrolidin-1-yl)ethyl)pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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