CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD153
Family Name Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibutramine Family
No. of Seeds 7 No. of Other Members 127
Family Centroid CFAMM00026920 Functional Category Approved Drug
Superfamily Monoamine reuptake inhibitor Sertraline Sibutramine Superfamily
Class Class 48

Cousin Family NamesSeedsMembers
Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Dopamine reuptake Inhibitor Brasofensine Family 1 0
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Zicronapine family 43 62
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 24
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 1 4
Sodium-dependent dopamine transporter inhibitor N-[[(1S,3S,4R,... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Kinesin-like protein KIF11 inhibitor 4-(4-chlorophenyl)-4,4-di... 1 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand (2S,... 5 5
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00026920 DAP000176 Approved Drug Sibutramine
CFAMM00026893 CHEMBL281288 Bioactive SureCN9257274
CFAMM00026900 CHEMBL1684047 Bioactive AGN-PC-093IQX
CFAMM00026892 CHEMBL432401 Bioactive (3S,4S)-4-butyl-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane
CFAMM00026869 CHEMBL321888 Bioactive (3S,4S)-3-(4-chlorophenyl)-8-methyl-4-propyl-8-azabicyclo[3.2.1]octane
CFAMM00026912 CHEMBL27336 Bioactive (3S,4S)-3-(4-chlorophenyl)-4-ethyl-8-methyl-8-azabicyclo[3.2.1]octane
CFAMM00026859 CHEMBL134341 Bioactive 3-(4-chlorophenyl)-7-methyl-7-azabicyclo[2.2.1]heptane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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