Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118 5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680 Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140 Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26 Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82 Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45 Dopamine reuptake Inhibitor Brasofensine Family 1 0 Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89 5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38 Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131 Zicronapine family 43 62 D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7 Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 24 Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15 Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71 Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2 Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1 Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2 Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9 Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0 Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4 Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3 Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4 Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6 Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0 Transporter and Sodium-dependent dopamine transporter inhibito... 3 0 Transporter and Sodium-dependent serotonin transporter inhibit... 4 8 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 1 4 Sodium-dependent dopamine transporter inhibitor N-[[(1S,3S,4R,... 1 0 Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4 Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12 Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1 5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0 Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5 D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1 Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0 D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1 C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0 Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6 Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0 Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0 Kinesin-like protein KIF11 inhibitor 4-(4-chlorophenyl)-4,4-di... 1 2 Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 1 D(1A) dopamine receptor and D(3) dopamine receptor ligand (2S,... 5 5 Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00026860 CHEMBL322067 Bioactive
AC1Q3O5O CFAMM00026936 CHEMBL219335 Bioactive
AGN-PC-00ACMW CFAMM00026929 CHEMBL103829 Bioactive
SureCN3827721 CFAMM00026979 CHEMBL1813317 Bioactive
(3aR,7aS)-7a-(3,4-dichlorophenyl)-2-ethyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00026879 CHEMBL1683872 Bioactive
AGN-PC-09QKF5 CFAMM00026943 CHEMBL534501 Bioactive
(1R,2S,9aR)-1-(3,4-dichlorophenyl)-2-ethyl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine;hydrochloride CFAMM00026956 CHEMBL494624 Bioactive
(1S,3S,4S,5R)-3-(4-chlorophenyl)-4-(2,2-dibromoethenyl)-8-methyl-8-azabicyclo[3.2.1]octane;hydrochloride CFAMM00026886 CHEMBL300647 Bioactive
A31472 CFAMM00026949 CHEMBL316988 Bioactive
SureCN6684370 CFAMM00026928 CHEMBL173861 Bioactive
AC1O3H6V CFAMM00026915 CHEMBL143360 Bioactive
BD-1047 CFAMM00026878 CHEMBL1683873 Bioactive
AGN-PC-09QKF6 CFAMM00026942 CHEMBL373710 Bioactive
2-[1-(4-chlorophenyl)-4-methylpentyl]piperidine CFAMM00026865 CHEMBL1683880 Bioactive
AGN-PC-09QGY5 CFAMM00026871 CHEMBL1683889 Bioactive
AGN-PC-09QGYM CFAMM00026921 CHEMBL556365 Bioactive
(1R,9aR)-1-(3,4-dichlorophenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine;hydrochloride CFAMM00026948 CHEMBL1743803 Bioactive
Mcn 5707 CFAMM00026977 CHEMBL45491 Bioactive
A-23887 CFAMM00026914 CHEMBL494814 Bioactive
(1S,3S,4R,5R)-3-(4-chlorophenyl)-8-methyl-4-(2-phenylethynyl)-8-azabicyclo[3.2.1]octane;hydrochloride CFAMM00026940 CHEMBL32797 Bioactive
(6R,10bS)-6-(4-chlorophenyl)-10b-methyl-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinoline CFAMM00026983 CHEMBL220247 Bioactive
AGN-PC-00ACMV CFAMM00026933 CHEMBL2321996 Bioactive
(3R)-3-(3,4-dichlorophenyl)-1-methyl-2,3,4,7-tetrahydroazepine CFAMM00026899 CHEMBL1684044 Bioactive
AGN-PC-04SSM2 CFAMM00026976 CHEMBL219653 Bioactive
2-[1-(4-chlorophenyl)-2-cyclopentylethyl]piperidine CFAMM00026913 CHEMBL449047 Bioactive
(1S,3S,4R,5R)-3-(4-chlorophenyl)-4-ethynyl-8-methyl-8-azabicyclo[3.2.1]octane;hydrochloride CFAMM00026926 CHEMBL1813487 Bioactive
(3aS,7aS)-7a-[(3,4-dichlorophenyl)methyl]-2-methyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00026891 CHEMBL558395 Bioactive
(1R,2R,9aR)-1-(3,4-dichlorophenyl)-2-ethyl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine;hydrochloride CFAMM00026982 CHEMBL1813314 Bioactive
(3aS,7aR)-7a-(3,4-dichlorophenyl)-2-methyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00026996 CHEMBL1743790 Bioactive
(6S,10bR)-6-(3-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide CFAMM00026959 CHEMBL1813484 Bioactive
(3aR,6aS)-3a-(3,4-dichlorophenyl)-2-methyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole CFAMM00026975 CHEMBL1172902 Bioactive
SureCN13039295 CFAMM00026882 CHEMBL1683877 Bioactive
AGN-PC-09QIPA CFAMM00026938 CHEMBL387117 Bioactive
2-[1-(3,4-dichlorophenyl)-3-methylbutyl]-1-methylpiperidine CFAMM00026890 CHEMBL1813478 Bioactive
(3aS,6aR)-3a-(3,4-dichlorophenyl)-2-methyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole CFAMM00026918 CHEMBL356688 Bioactive
NCGC00024624-01 CFAMM00026881 CHEMBL1683874 Bioactive
AGN-PC-09QJJF CFAMM00026861 CHEMBL378536 Bioactive
AGN-PC-0764XC CFAMM00026874 CHEMBL106437 Bioactive
BD 737 CFAMM00026867 CHEMBL1683882 Bioactive
AGN-PC-09QGY6 CFAMM00026880 CHEMBL1683875 Bioactive
AGN-PC-09QGY4 CFAMM00026944 CHEMBL2326691 Bioactive
3-(3,4-dichlorophenyl)-1-methylazepane CFAMM00026909 CHEMBL2321995 Bioactive
3-(3,4-dichlorophenyl)-1-methyl-2,3,4,7-tetrahydroazepine CFAMM00026963 CHEMBL2181454 Bioactive
(4-chlorophenyl)methyl-[[(1S,5R)-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methyl]-dimethylazanium;iodide CFAMM00026916 CHEMBL1200765 Bioactive
SIBUTRAMINE HCl CFAMM00026992 CHEMBL295880 Bioactive
(Z,4R)-4-(4-chlorophenyl)-N-[(2-methylpropan-2-yl)oxy]-1-azabicyclo[3.2.1]octan-6-imine CFAMM00026908 CHEMBL59047 Bioactive
CHEMBL59047 CFAMM00026985 CHEMBL295882 Bioactive
(4S)-4-(4-chlorophenyl)-N-methoxy-1-azabicyclo[3.2.1]octan-6-imine CFAMM00026907 CHEMBL1642910 Bioactive
1-[(2S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N,N-dimethylmethanamine CFAMM00026984 CHEMBL298420 Bioactive
(E,4R)-4-(4-chlorophenyl)-N-methoxy-1-azabicyclo[3.2.1]octan-6-imine CFAMM00026934 CHEMBL113336 Bioactive
4-Piperidinecarbonitrile, 4-(3,4-dichlorophenyl)-1-methyl- CFAMM00026961 CHEMBL287032 Bioactive
AGN-PC-00FBR6 CFAMM00026990 CHEMBL2048227 Bioactive
4-(4-chlorophenyl)-1-propylpiperidine CFAMM00026906 CHEMBL1642911 Bioactive
1-[(2R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-N,N-dimethylmethanamine CFAMM00026969 CHEMBL219707 Bioactive
2-[1-(4-chlorophenyl)-2-cyclohexylethyl]piperidine CFAMM00026857 CHEMBL537429 Bioactive
(1R,9aR)-1-(2-chlorophenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine;hydrochloride CFAMM00026947 CHEMBL102999 Bioactive
AC1O3LMV CFAMM00026960 CHEMBL47188 Bioactive
(Z,4S)-4-(4-chlorophenyl)-N-methoxy-1-azabicyclo[3.2.1]octan-6-imine CFAMM00026989 CHEMBL2205697 Bioactive
2-(4-chlorophenyl)ethyl-[[(1S,5R)-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methyl]-dimethylazanium;iodide CFAMM00026863 CHEMBL1683885 Bioactive
AGN-PC-09QJJG CFAMM00026876 CHEMBL1683871 Bioactive
(1-(3,4-Dichlorophenyl)Cyclohexyl)Methanamine CFAMM00026939 CHEMBL557576 Bioactive
AGN-PC-005DJM CFAMM00026953 CHEMBL104992 Bioactive
SureCN5935213 CFAMM00026919 CHEMBL441864 Bioactive
2-[1-(4-chlorophenyl)-4-phenylbutyl]piperidine CFAMM00026946 CHEMBL373773 Bioactive
2-[1-(4-chlorophenyl)-2-phenylethyl]piperidine CFAMM00026856 CHEMBL364469 Bioactive
AGN-PC-004OCS CFAMM00026925 CHEMBL322365 Bioactive
(3S,4S)-3-(4-chlorophenyl)-4-hexyl-8-methyl-8-azabicyclo[3.2.1]octane CFAMM00026904 CHEMBL1684048 Bioactive
AGN-PC-09QKGC CFAMM00026974 CHEMBL598270 Bioactive
Clofilium tosylate CFAMM00026987 CHEMBL279352 Bioactive
SureCN433751 CFAMM00026910 CHEMBL45111 Bioactive
(4R)-4-(4-chlorophenyl)-N-methoxy-1-azabicyclo[3.2.1]octan-6-imine CFAMM00026958 CHEMBL1813486 Bioactive
(3aR,7aR)-7a-[(3,4-dichlorophenyl)methyl]-2-methyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00026937 CHEMBL219334 Bioactive
2-[1-(4-chlorophenyl)-2-ethylbutyl]piperidine CFAMM00026854 CHEMBL1813306 Bioactive
(3aR,7aS)-7a-(2,4-dichlorophenyl)-2-methyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00026957 CHEMBL107717 Bioactive
N'-[2-(3,4-dichlorophenyl)ethyl]-N,N'-dimethyl-N-(4-pyrrolidin-1-ylbutyl)propane-1,3-diamine CFAMM00026923 CHEMBL75300 Bioactive
AGN-PC-074IK5 CFAMM00026950 CHEMBL75036 Bioactive
AGN-PC-074IIN CFAMM00026873 CHEMBL285403 Bioactive
SureCN10376923 CFAMM00026887 CHEMBL374769 Bioactive
2-[1-(4-chlorophenyl)-3,3-dimethylbutyl]piperidine CFAMM00026902 CHEMBL1684042 Bioactive
AGN-PC-04SSM3 CFAMM00026866 CHEMBL2048525 Bioactive
1-[(1S,3S,4R,5R)-3-(4-chlorophenyl)-8-(3-fluoranylpropyl)-8-azabicyclo[3.2.1]octan-4-yl]-N,N-dimethylmethanamine CFAMM00026972 CHEMBL32270 Bioactive
(6S,10bS)-9-chloro-6-(4-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline CFAMM00026922 CHEMBL219281 Bioactive
2-[1-(4-chlorophenyl)-3-phenylpropyl]piperidine CFAMM00026978 CHEMBL324620 Bioactive
NCI60_038432 CFAMM00026872 CHEMBL1743789 Bioactive
(6R,10bS)-6-(2-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide CFAMM00026901 CHEMBL1684043 Bioactive
AGN-PC-04SSK3 CFAMM00026858 CHEMBL430466 Bioactive
(1S,2S)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-pyrrolidin-1-ylcyclohexan-1-amine CFAMM00026885 CHEMBL358368 Bioactive
1-[3-(3,4-dichlorophenyl)-2-bicyclo[2.2.2]octanyl]-N,N-dimethylmethanamine CFAMM00026927 CHEMBL2115570 Bioactive
(3S,4S)-4-(2-chloroethenyl)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane CFAMM00026954 CHEMBL559186 Bioactive
(1S,9aR)-1-(3,4-dichlorophenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine;hydrochloride CFAMM00026864 CHEMBL1683886 Bioactive
AGN-PC-09QGY7 CFAMM00026877 CHEMBL1683870 Bioactive
SureCN3518106 CFAMM00026870 CHEMBL1683888 Bioactive
AGN-PC-09QKFC CFAMM00026883 CHEMBL218848 Bioactive
2-[1-(4-chlorophenyl)-2-methylpropyl]piperidine CFAMM00026968 CHEMBL2206523 Bioactive
4-(4-chlorophenyl)-2-methyl-3,4-dihydro-1H-isoquinoline CFAMM00026905 CHEMBL2321997 Bioactive
(3S)-3-(3,4-dichlorophenyl)-1-methyl-2,3,4,7-tetrahydroazepine CFAMM00026898 CHEMBL1684045 Bioactive
AGN-PC-093IQV CFAMM00026862 CHEMBL1683884 Bioactive
SureCN3517701 CFAMM00026988 CHEMBL375118 Bioactive
2-[(4-chlorophenyl)-cyclopentylmethyl]piperidine CFAMM00026875 CHEMBL1683878 Bioactive
AGN-PC-09QLBC CFAMM00026967 CHEMBL319805 Bioactive
SureCN7084956 CFAMM00026981 CHEMBL1813315 Bioactive
(3aR,7aS)-7a-(3,4-dichlorophenyl)-2-methyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00026994 CHEMBL1743796 Bioactive
(6S,10bS)-6-(3-chlorophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide CFAMM00026855 CHEMBL2048524 Bioactive
1-[(1S,3S,4R,5R)-3-(4-chlorophenyl)-8-(2-fluoranylethyl)-8-azabicyclo[3.2.1]octan-4-yl]-N,N-dimethylmethanamine CFAMM00026868 CHEMBL1683883 Bioactive
SureCN3519163 CFAMM00026931 CHEMBL335204 Bioactive
3-(4-chlorophenyl)-7-ethyl-7-azabicyclo[2.2.1]heptane CFAMM00026889 CHEMBL141893 Bioactive
AGN-PC-003SR3 CFAMM00026903 CHEMBL316797 Bioactive
SureCN5935258 CFAMM00026980 CHEMBL1813316 Bioactive
(3aS,7aR)-7a-(3,4-dichlorophenyl)-2-ethyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00026993 CHEMBL1643898 Bioactive
2-butyl-3-(4-chlorophenyl)-1-azabicyclo[2.2.2]oct-2-ene CFAMM00026896 CHEMBL323476 Bioactive
NCI60_038430 CFAMM00026973 CHEMBL9484 Bioactive
Clofilium CFAMM00026894 20302210 Patent Compound
AGN-PC-02RNOZ CFAMM00026935 54512673 Patent Compound
AGN-PC-0A7ADS CFAMM00026962 19823784 Patent Compound
AGN-PC-02KLNO CFAMM00026991 57194860 Patent Compound
AGN-PC-0BP96E CFAMM00026955 19823721 Patent Compound
AGN-PC-02KLM9 CFAMM00026971 23342852 Patent Compound
SureCN11486228 CFAMM00026932 13083344 Patent Compound
AGN-PC-00KT3H CFAMM00026952 115925 Patent Compound
3-(4-chlorophenyl)-N,N-dimethylpropan-1-amine CFAMM00026945 12951701 Patent Compound
AGN-PC-00K85V CFAMM00026897 3732780 Patent Compound
4-[(4-chlorophenyl)methyl]piperidine CFAMM00026924 13189987 Patent Compound
AGN-PC-00LD57 CFAMM00026951 13083296 Patent Compound
AGN-PC-00KT2B CFAMM00026966 22458793 Patent Compound
AGN-PC-03P7JH CFAMM00026917 54287336 Patent Compound
SureCN7414359 CFAMM00026930 22649570 Patent Compound
AGN-PC-00KBAV CFAMM00026986 9922196 Patent Compound
AGN-PC-0CQ6J3
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
