CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name D(2) dopamine receptor ligand catecholamine Dopamine family
No. of Seeds 9 No. of Other Members 170
Family Centroid CFAMM00002685 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily D(2) dopamine receptor ligand catecholamine Dopamine Superfamily
Class Class 16

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha adrenergic receptor ligand L-Tyrosine derivative Methyld... 2 3
Alpha-2 adrenergic receptor Ligand Oxymetazoline Family 5 4
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor ligand Dienestrol Family 35 440
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benz... 2 6
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Lethal factor Inhibitor N-(3,4,5-trihydroxyphenethyl)oleamide ... 1 3
Epidermal growth factor receptor Ligand 4-(2-nitrovinyl)benzen... 3 1
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Alpha-1D adrenergic receptor ligand AGN-PC-0761MO family 1 0
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Phenethylamines Metabolite Tyramine-O-sulfate Family 1 1


External ID

Functional Category

Molecule Name

CFAMM00002685 DAP000212 Approved Drug Dopamine
CFAMM00002801 DAP000016 Approved Drug Norepinephrine
CFAMM00002611 DNAP001647 Approved Drug Dopamine hydrochloride
CFAMM00002798 DNC010273 Investigative Drug 6-fluoronorepinehprine
CFAMM00002731 DNC012630 Investigative Drug 6-(2-Amino-ethyl)-biphenyl-2,3,4'-triol
CFAMM00002797 DNC010272 Investigative Drug 2-fluoronorepinehprine
CFAMM00002697 DNC012629 Investigative Drug 6-(2-Amino-ethyl)-biphenyl-2,3-diol
CFAMM00002704 DNC012645 Investigative Drug LEVONORDEFRIN
CFAMM00002616 DNC012050 Investigative Drug METHYLNORADRENALINE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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