CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Peptidyl-prolyl cis-trans isomerase A and Peptidyl-prolyl cis-trans isomerase B Inhibitor L-proline Family
No. of Seeds 2 No. of Other Members 35
Family Centroid CFAMM00029867 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Peptidyl-prolyl cis-trans isomerase A and Peptidyl-prolyl cis-trans isomerase B Inhibitor L-proline Superfamily
Class Class 156

Cousin Family NamesSeedsMembers
Glutamine receptor Ligand L-alanyl-l-glutamine Family 3 101
Metabotropic glutamate receptor 2 Ligand (2r,4r)-4-aminopyrrol... 1 2
C-X-C motif chemokine 10 Inhibitor N-methylleucine Family 1 11
D-alanyl-D-alanine carboxypeptidase Inhibitor Glycyl-l-alpha-a... 5 89
Sodium/glucose cotransporter 1 Inhibitor Qcpac Family 4 7
Sodium/glucose cotransporter 1 Inhibitor Qspac Family 3 8
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 6 3
Nucleotide-binding oligomerization domain-containing protein 1... 14 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor Gl... 1 0
Amino Acids and Derivatives Metabolite Saccharopine Family 2 1
Pyrrolidines Metabolite 4-Hydroxystachydrine Family 3 2
Amino Acids and Derivatives Metabolite Lysinoalanine Family 1 1
Pyrrolidines Metabolite D-1-Amino-2-pyrrolidinecarboxylic acid... 2 0
Carboxylic Acids and Derivatives Metabolite beta-Alanyl-L-argi... 3 1
ethyl (2S)-5-oxopyrrolidine-2-carboxylate NP Ethyl Pyroglutama... 1 2


External ID

Functional Category

Molecule Name

CFAMM00029867 DAP000198 Approved Drug L-Proline
CFAMM00029877 DNC002533 Investigative Drug Pyroglutamic Acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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