CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name AMP-activated protein kinase Inhibitor Phenformin Family
No. of Seeds 5 No. of Other Members 14
Family Centroid CFAMM00029973 Functional Category Approved Drug with Human Metabolite
Superfamily AMP-activated protein kinase Inhibitor Phenformin Superfamily
Class Class 45

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Bethanidine Family 2 22
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Alpha adrenergic receptor Ligand Tolazoline Family 7 51
Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Aldehyde oxidase Inhibitor Benzamidine Family 2 6
Alpha-2A adrenergic receptor Ligand Brl 44408 Family 1 0
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
5-hydroxytryptamine receptor 1D and Alpha-1A adrenergic recept... 3 22
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0
Aminopeptidase N Inhibitor (1-amino-2-phenyl-ethyl)-phosphinic... 3 11
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Nitric oxide synthase, brain Inhibitor 1-(benzhydrylamino)etha... 1 4
Nitric oxide synthase, inducible and Nuclear factor NF-kappa-B... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 6
Dihydrofolate reductase inhibitor 5-[(3,5-dimethylphenyl)methy... 4 9


External ID

Functional Category

Molecule Name

CFAMM00029973 DAP000206 Approved Drug Phenformin
CFAMM00029978 DNAP001705 Approved Drug Iobenguane I-123
CFAMM00029970 DNCL002685 Clinical Trial Drug Metaiodobenzylguanidine I-131
CFAMM00029963 DNC009023 Investigative Drug N-benzylacetimidamide hydrobromide
CFAMM00029961 DNC009024 Investigative Drug (S)-N-(1-phenylethyl)acetimidamide hydrobromide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



70845 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543