CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Dopamine receptor ligand L-Tyrosine derivative Levodopa Family
No. of Seeds 4 No. of Other Members 59
Family Centroid CFAMM00030738 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily biogenic amine receptor, Tyrosine metabolism enzyme binding L-Tyrosine derivative Superfamily
Class Class 163

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha adrenergic receptor ligand L-Tyrosine derivative Methyld... 2 3
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Zucapsacin family 7 177
Thymopentin family 20 133
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Epidermal growth factor receptor Ligand AG-538 Family 5 11
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Sodium-dependent dopamine transporter inhibitor AC1MIIGH family 2 0
Aminopeptidase N and Cytosol aminopeptidase inhibitor AGN-PC-0... 1 0
Alpha-1D adrenergic receptor ligand AGN-PC-0761MO family 1 0
Neuropeptide S receptor and Metabotropic glutamate receptor 1 ... 1 2
Amino Acids and Derivatives Metabolite Caffeoyl aspartic acid ... 1 0


External ID

Functional Category

Molecule Name

CFAMM00030738 DAP000209 Approved Drug Levodopa
CFAMM00030742 DNAP001383 Approved Drug Melevodopa
CFAMM00030712 DNAP001468 Approved Drug Droxidopa
CFAMM00030702 DNC002682 Investigative Drug Meta-Tyrosine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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