CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD181
Family Name Vitamin D3 receptor ligand Vitamin D analog Calcitriol Family
No. of Seeds 49 No. of Other Members 120
Family Centroid CFAMM00030931 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Vitamin D3 receptor ligand Vitamin D analog Superfamily
Class Class 165

Cousin Family NamesSeedsMembers
Vitamin D3 receptor ligand Vitamin D analog Cholecalciferol Fa... 7 270
Trimegestone family 7 25
HE3286 family 5 34
Lanosterol synthase Inhibitor Lanosterol Family 2 62
Nuclear receptor ROR-alpha Ligand Cholesterol-sulfate Family 1 0
Prostaglandin G/H synthase 2 Inhibitor 8alpha,19-dihydroxylabd... 2 10
Acetylcholinesterase and Cholinesterase Inhibitor 24-ethylchol... 1 2
Vitamin D3 receptor ligand (1R,3R)-5-[(2E)-2-[(7aS)-1-[1-(2-et... 8 2
Vitamin D3 receptor ligand butyl 1-[(E,1R,4R)-4-[(1R,3aS,4E,7a... 2 4
Vitamin D3 receptor ligand (5R)-5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[... 81 9
Vitamin D3 receptor ligand (2E,4R,6S)-2-[(2Z)-2-[(7aR)-1-[(2R)... 2 0
Vitamin D3 receptor ligand (1R,3R)-5-[(E,5R,7S)-11-hydroxy-5,7... 2 2
7-dehydrocholesterol reductase inhibitor [(3R)-3-[(3S,10R,13R)... 1 5
Protein kinase C zeta type and Transcription factor p65 inhibi... 2 0
Prenol Lipids Metabolite Zeaxanthin Family 10 4
Prenol Lipids Metabolite Fasciculol C Family 1 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00030919 DNAP001372 Approved Drug Maxacalcitol
CFAMM00030931 DAP000289 Approved Drug Calcitriol
CFAMM00030913 DAP000292 Approved Drug Calcipotriol
CFAMM00030942 DNAP001360 Approved Drug Falecalcitrol
CFAMM00030905 DAP000211 Approved Drug Paricalcitol
CFAMM00030985 DNAP001436 Approved Drug Tacalcitol
CFAMM00031007 CHEMBL2436597 Bioactive (1R,3R)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(2S)-3-hydroxy-2,3-dimethylbutoxy]ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00031020 CHEMBL2058272 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-5-ethyl-5-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030847 CHEMBL1630754 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6R)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030903 CHEMBL2059268 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-6-hydroxy-3,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030877 CHEMBL605525 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030962 CHEMBL454141 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3R,5S)-3-butyl-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030895 CHEMBL1830165 Bioactive (1R,2E,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-butan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropylidene)-4-methylidenecyclohexane-1,3-diol
CFAMM00030998 CHEMBL607373 Bioactive (1R,3R)-5-[(2E)-2-[(1S,3aS,7aR)-1-(5-hydroxy-5-methylhexyl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030817 CHEMBL2059272 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S)-6-hydroxy-3,3,6-trimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030869 CHEMBL2172537 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7R,7aR)-7-(7-hydroxy-7-methyloctyl)-1-[(2R)-5-hydroxypentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030846 CHEMBL1630757 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S,6S)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylcyclohexane-1,3-diol
CFAMM00030916 CHEMBL226328 Bioactive (1R,3R)-2-(2-fluoroethylidene)-5-[(2E)-2-[1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol
CFAMM00030894 CHEMBL1830166 Bioactive (1R,2E,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-(2-methylbutan-2-yl)-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropylidene)-4-methylidenecyclohexane-1,3-diol
CFAMM00030868 CHEMBL2172539 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7R,7aR)-7-(7-hydroxy-7-methyloctyl)-1-[(2S)-1-hydroxypropan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030924 CHEMBL2058273 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3,5-diethyl-5-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030988 CHEMBL222195 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,7aR)-1-[(2S,3R)-3-ethyl-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030845 CHEMBL1630756 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6S)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylcyclohexane-1,3-diol
CFAMM00030893 CHEMBL1830167 Bioactive (1R,2E,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-4-methylpentan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropylidene)-4-methylidenecyclohexane-1,3-diol
CFAMM00030867 CHEMBL2172538 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7R,7aR)-1-[(2R)-4-hydroxybutan-2-yl]-7-(7-hydroxy-7-methyloctyl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00031003 CHEMBL596532 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(2S)-6-hydroxy-6-methylheptan-2-yl]-1,2,3,3a,5,6,7,7a-octahydroinden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030827 CHEMBL594078 Bioactive (1R,3R)-5-[(2E)-2-[(1S,3aR,7aR)-1-(5-hydroxy-5-methylhexyl)-1,2,3,3a,5,6,7,7a-octahydroinden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030844 CHEMBL1630759 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S,6R)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylcyclohexane-1,3-diol
CFAMM00030892 CHEMBL1830168 Bioactive (1R,2E,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2S)-4-methylpentan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropylidene)-4-methylidenecyclohexane-1,3-diol
CFAMM00030977 CHEMBL220846 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,7aR)-1-[(2S,3R)-6-hydroxy-3,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030922 CHEMBL299680 Bioactive (1R,3S,5E)-5-[(2Z)-2-[(3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-3a,7a-dimethyl-1,2,3,5,6,7-hexahydroinden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030850 CHEMBL1630753 Bioactive (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S,6S)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2,4-dimethylidenecyclohexane-1,3-diol
CFAMM00030866 CHEMBL2059270 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S,3S)-6-hydroxy-3,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030912 CHEMBL226380 Bioactive (1R,3R)-2-(2-fluoroethylidene)-5-[(2E)-2-[1-[(2S)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol
CFAMM00031016 CHEMBL454947 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S,5S)-3-butyl-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030843 CHEMBL1630758 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6R)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylcyclohexane-1,3-diol
CFAMM00030891 CHEMBL375811 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,7aR)-1-[(2S,3R)-3-butyl-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00031022 CHEMBL2058274 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-butyl-5-ethyl-5-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030849 CHEMBL1630752 Bioactive (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,6S)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2,4-dimethylidenecyclohexane-1,3-diol
CFAMM00030865 CHEMBL2059271 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-3,3,6-trimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00031015 CHEMBL454124 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S,3S)-3-(2-hydroxyethyl)heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030898 CHEMBL2059267 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3R)-6-hydroxy-3,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030904 CHEMBL2059269 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S,3R)-6-hydroxy-3,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030848 CHEMBL1630755 Bioactive (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2S,6R)-6-hydroxyheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexane-1,3-diol
CFAMM00030896 CHEMBL1830164 Bioactive (1R,2E,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-butan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropylidene)-4-methylidenecyclohexane-1,3-diol
CFAMM00030889 CHEMBL454123 Bioactive (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-(2-hydroxyethyl)heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CFAMM00030954 DCL000782 Clinical Trial Drug Doxercalciferol
CFAMM00031009 DNC002736 Investigative Drug 19-nor-14-epi-23-yne-1,25 dihydroxyvitamin D3
CFAMM00031008 DNC002735 Investigative Drug Seocalcitol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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