CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD182
Family Name Opioid receptor ligand opiate Levorphanol Family
No. of Seeds 18 No. of Other Members 537
Family Centroid CFAMM00031377 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Opioid receptor, Sigma receptor ligand opiate Levorphanol Dextromethorphan Superfamily
Class Class 166

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Histamine H1 receptor Ligand Terfenadine Family 3 50
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
D(2) dopamine receptor Ligand N-0923 Family 6 41
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Delta-type opioid receptor Ligand Tonazocine Mesylate Family 1 0
Histamine H3 receptor Ligand A-331440 Family 6 7
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 18 25
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
D(3) dopamine receptor ligand S 14297 family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
D(2) dopamine receptor and D(1A) dopamine receptor ligand (6aR... 2 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00031225 DAP000214 Approved Drug Butorphanol
CFAMM00031071 DAP000356 Approved Drug Pentazocine
CFAMM00031526 DAP000348 Approved Drug Levallorphan
CFAMM00031377 DAP000268 Approved Drug Levorphanol
CFAMM00031584 CHEMBL291468 Bioactive (-)-cyclorphan
CFAMM00031107 CHEMBL1254682 Bioactive levallorphan
CFAMM00031400 CHEMBL316632 Bioactive Phenazocine [INN]
CFAMM00031572 CHEMBL2062261 Bioactive Levorphanol tartrate
CFAMM00031135 CHEMBL2367800 Bioactive CHEMBL2367800
CFAMM00031563 DNC006050 Investigative Drug MCL-117
CFAMM00031306 DNC008747 Investigative Drug METAZOCINE
CFAMM00031562 DNC006051 Investigative Drug (-)-cyclorphan
CFAMM00031252 DNC012655 Investigative Drug BREMAZOCINE
CFAMM00031424 DNC012712 Investigative Drug LEVORPHANOL HYDROCHLORIDE
CFAMM00031312 DNC008748 Investigative Drug PHENAZOCINE
CFAMM00031307 DNC008745 Investigative Drug CYCLAZOCINE
CFAMM00031564 DNC006052 Investigative Drug BUTORPHAN
CFAMM00031292 DNC010087 Investigative Drug 2-Hydroxymethyl-3-hydroxymorphinan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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