CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD188
Family Name D(2) dopamine receptor Ligand Nemonapride Family
No. of Seeds 70 No. of Other Members 283
Family Centroid CFAMM00033669 Functional Category Approved Drug with Human Metabolite
Superfamily D(2) dopamine receptor Ligand Nemonapride Superfamily
Class Class 171

Cousin Family NamesSeedsMembers
Insulin receptor Ligand Meglitinides Family 9 25
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
5-hydroxytryptamine receptor 3A Ligand KB-6806 Family 12 11
Cinitapride family 4 22
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Tubulin Inhibitor WR85915 Family 3 15
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Substance-K receptor Ligand MEN-14933 Family 13 154
5-hydroxytryptamine receptor 4 Ligand SB-207710 Family 10 5
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 4 ligand 2-(4-pyridin-4-ylpiperaz... 2 1
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 4 ligand RS100235 family 3 1
5-hydroxytryptamine receptor 4 ligand AGN-PC-087VMU family 1 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
D(2) dopamine receptor ligand 2-bromo-3-chloro-N-[[(2S)-1-ethy... 1 1
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
Trace amine-associated receptor 1 ligand EPPTB family 4 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 2 0
5-hydroxytryptamine receptor 4 ligand AGN-PC-01LVA9 family 3 11
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
C-C chemokine receptor type 1 ligand 2-[(2S)-3-(5-chlorospiro[... 2 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 4 ligand AGN-PC-00GPBT family 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 5
5-hydroxytryptamine receptor 4 ligand CHEBI:64081 family 1 1
Prostaglandin G/H synthase 2 inhibitor AGN-PC-09QGM1 family 2 1
Nonstructural protein 1 and Thioredoxin glutathione reductase ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00033683 DAP000530 Approved Drug Metoclopramide
CFAMM00033669 DAP001497 Approved Drug Nemonapride
CFAMM00033639 DAP000222 Approved Drug Cisapride
CFAMM00033725 CHEMBL173089 Bioactive AGN-PC-0759GM
CFAMM00033911 CHEMBL425329 Bioactive 4-amino-N-[1-[[1-(3-amino-2-methylpropanoyl)piperidin-4-yl]methyl]piperidin-4-yl]-5-chloro-2-methoxybenzamide
CFAMM00033862 CHEMBL1836061 Bioactive 4-amino-5-chloro-2-methoxy-N-[(1R,5R)-8-(oxolan-2-ylmethyl)-8-azabicyclo[3.2.1]octan-3-yl]benzamide
CFAMM00033876 CHEMBL328866 Bioactive SureCN6215657
CFAMM00033704 CHEMBL172802 Bioactive AGN-PC-0759GI
CFAMM00033635 CHEMBL172074 Bioactive AGN-PC-0759FN
CFAMM00034006 CHEMBL368213 Bioactive AGN-PC-0759GD
CFAMM00033917 CHEMBL2093036 Bioactive 4-amino-5-chloro-N-[(3S)-1-ethylazepan-3-yl]-2-methoxybenzamide
CFAMM00033749 CHEMBL1169525 Bioactive 4-amino-5-chloro-N-[(6S)-8-[(4-fluorophenyl)methyl]-8-azabicyclo[3.2.1]octan-6-yl]-2-methoxybenzamide
CFAMM00033790 CHEMBL92192 Bioactive N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(prop-2-enoylamino)benzamide
CFAMM00033818 CHEMBL557867 Bioactive 4-amino-5-chloro-N-[1-[5-(1,3-dioxoisoindol-2-yl)pentyl]piperidin-4-yl]-2-methoxybenzamide
CFAMM00033676 CHEMBL163519 Bioactive 4-amino-N-(1-benzyl-4-methyl-1,4-diazepan-6-yl)-5-chloro-2-methoxybenzamide
CFAMM00034004 CHEMBL326454 Bioactive N-[(3R,4R)-1-benzyl-4-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide
CFAMM00033916 CHEMBL2093034 Bioactive 4-amino-5-chloro-N-[(6S)-1-ethyl-4-methyl-1,4-diazepan-6-yl]-2-methoxybenzamide
CFAMM00033838 CHEMBL199866 Bioactive 4-amino-5-chloro-2-methoxy-N-[[(1S,4R,8S)-4-methyl-2,3,5,6,7,8-hexahydro-1H-pyrrolizin-4-ium-1-yl]methyl]benzamide;iodide
CFAMM00033695 CHEMBL2448165 Bioactive CHEMBL2448165
CFAMM00033817 CHEMBL28992 Bioactive (S)-zacopride
CFAMM00033830 CHEMBL346973 Bioactive AGN-PC-00FLBR
CFAMM00033754 CHEMBL174524 Bioactive AGN-PC-0759GP
CFAMM00033688 CHEMBL172899 Bioactive AGN-PC-0759FI
CFAMM00033702 CHEMBL330318 Bioactive N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-[(2,2,2-trifluoroacetyl)amino]benzamide
CFAMM00033963 CHEMBL432681 Bioactive AGN-PC-073MCE
CFAMM00033958 CHEMBL562636 Bioactive 4-amino-5-chloro-2-methoxy-N-[1-(8-piperidin-1-yloctyl)piperidin-4-yl]benzamide
CFAMM00033802 CHEMBL93021 Bioactive N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(2-methylpropanoylamino)benzamide
CFAMM00033894 CHEMBL316317 Bioactive N-[(3R)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclobutanecarbonylamino)-2-methoxybenzamide
CFAMM00033674 CHEMBL91859 Bioactive 5-chloro-4-(cyclopropanecarbonylamino)-2-methoxy-N-[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]benzamide
CFAMM00033794 CHEMBL122445 Bioactive AGN-PC-0752KG
CFAMM00033859 CHEMBL315446 Bioactive N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclobutanecarbonylamino)-2-methoxybenzamide
CFAMM00033764 CHEMBL156348 Bioactive SureCN9117930
CFAMM00033654 CHEMBL274491 Bioactive nemonapride
CFAMM00033632 CHEMBL27846 Bioactive (R)-zacopride
CFAMM00033851 CHEMBL111749 Bioactive N-[(3R,4S)-1-benzyl-4-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide
CFAMM00033680 CHEMBL156977 Bioactive 4-amino-N-(1-butyl-1-azoniabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide;bromide
CFAMM00033693 CHEMBL109912 Bioactive N-[(3S,4S)-1-benzyl-3-methylpiperidin-4-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide
CFAMM00033746 CHEMBL74656 Bioactive REL-CISAPRIDE
CFAMM00033968 CHEMBL174284 Bioactive AGN-PC-0759KI
CFAMM00033879 CHEMBL112395 Bioactive AGN-PC-00JYBI
CFAMM00033721 CHEMBL319079 Bioactive N-[(3R)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclopropanecarbonylamino)-2-methoxybenzamide
CFAMM00033957 CHEMBL558226 Bioactive SC-52491
CFAMM00033752 CHEMBL327984 Bioactive 4-amino-N-[(3R)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxybenzamide
CFAMM00033893 CHEMBL562902 Bioactive 4-amino-5-chloro-2-methoxy-N-[1-(5-piperidin-1-ylpentyl)piperidin-4-yl]benzamide
CFAMM00033995 CHEMBL322802 Bioactive 4-amino-N-[(3S,4S)-1-benzyl-3-methylpiperidin-4-yl]-5-chloro-2-methoxybenzamide
CFAMM00033937 CHEMBL35180 Bioactive 4-amino-5-chloro-2-ethoxy-N-(2,3,5,6,7,8-hexahydro-1H-pyrrolizin-1-yl)benzamide
CFAMM00033950 CHEMBL172314 Bioactive 4-amino-N-[1-[[1-(2-aminoacetyl)piperidin-4-yl]methyl]piperidin-4-yl]-5-chloro-2-methoxybenzamide
CFAMM00033913 CHEMBL329106 Bioactive 4-amino-N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxybenzamide
CFAMM00033720 CHEMBL559548 Bioactive 4-amino-5-chloro-N-[1-[8-(1,3-dioxoisoindol-2-yl)octyl]piperidin-4-yl]-2-methoxybenzamide
CFAMM00033905 CHEMBL1628595 Bioactive [3H](S)-zacopride
CFAMM00033751 CHEMBL2448137 Bioactive CHEMBL2448137
CFAMM00033777 CHEMBL354180 Bioactive N-[[(3R,4S)-1-benzyl-4-methylpyrrolidin-3-yl]methyl]-5-chloro-2-methoxy-4-(methylamino)benzamide
CFAMM00033884 CHEMBL369037 Bioactive 4-amino-N-[1-[[1-(4-aminobutyl)piperidin-4-yl]methyl]piperidin-4-yl]-5-chloro-2-methoxybenzamide
CFAMM00034000 CHEMBL125237 Bioactive 154540-49-5
CFAMM00033928 CHEMBL428705 Bioactive AGN-PC-01Z0JI
CFAMM00033785 CHEMBL2448558 Bioactive AC1OCEVU
CFAMM00033761 CHEMBL156346 Bioactive 4-amino-5-chloro-N-(1,4-dimethyl-1,4-diazepan-6-yl)-2-methoxybenzamide
CFAMM00033993 CHEMBL164169 Bioactive 4-amino-N-(8-benzyl-8-azabicyclo[3.2.1]octan-3-yl)-5-chloro-2-methoxybenzamide
CFAMM00033904 CHEMBL93198 Bioactive N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(propanoylamino)benzamide
CFAMM00033776 CHEMBL186909 Bioactive AGN-PC-073NKK
CFAMM00033868 DCL000954 Clinical Trial Drug Renzapride
CFAMM00033987 DCL000566 Clinical Trial Drug MK-0646
CFAMM00033947 DNC010191 Investigative Drug Norcisapride
CFAMM00033940 DNC012741 Investigative Drug BRL-24682
CFAMM00033938 DNC012749 Investigative Drug BRL-25594
CFAMM00033737 DNC003562 Investigative Drug ZACOPRIDE
CFAMM00033956 DNC011919 Investigative Drug CLEBOPRIDE
CFAMM00033841 DNC011905 Investigative Drug BRL-26175
CFAMM00033891 DNC012918 Investigative Drug SC-52491
CFAMM00034007 DNC000959 Investigative Drug Mosapride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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