CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Adenosine receptor A3 ligand purine nucleoside Adenosine Family
No. of Seeds 47 No. of Other Members 847
Family Centroid CFAMM00034063 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Adenosine receptor, DNA binding purine nucleoside Adenosine analog Superfamily
Class Class 172

Cousin Family NamesSeedsMembers
Reverse transcriptase inhibitor nucleotide adenosine monophosp... 4 24
Adenosine deaminase Inhibitor Pentostatin Family 4 13
HIV reverse transcriptase inhibitor guanosine analog Didanosin... 20 166
HIV reverse transcriptase Inhibitor Abacavir Family 3 9
DNA Binder Adenine Family 19 55
DNA Binder purine nucleoside Adenosine analog Nelarabine Family 2 10
NADH-ubiquinone oxidoreductase chain 3 Inhibitor Nadh Family 4 11
Bucladesine family 1 1
Adenosine receptor A2a Ligand Regadenoson Family 10 22
Adenosine receptor A2a Ligand Atl-146e Family 33 94
P2Y purinoceptor 12 Inhibitor Ar-c69931 Mx Family 10 18
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
TG-C family 11 208
Reverse transcriptase Inhibitor Amdoxovir Family 1 2
Thyroid hormone receptor Ligand Dibrt Family 3 8
Histamine N-methyltransferase Inhibitor S-adenosyl-l-homocyste... 2 3
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Selenazole-... 2 1
Adenosylhomocysteinase Inhibitor D-eritadenine Family 2 1
Adenosine deaminase Inhibitor (2s,3r)-3-(6-amino-9h-purin-9-yl... 4 30
Adenosine receptor A1 Ligand Cyclopentyl-(9-ethyl-9h-purin-6-y... 10 3
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-brom... 10 1
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-brom... 1 10
Adenosylhomocysteinase Inhibitor 4(z)-(5'-deoxyadenosin-5'-yli... 2 1
cAMP-dependent protein kinase type I-alpha regulatory subunit ... 12 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Mitogen-activated p... 1 1
Asparagine synthetase [glutamine-hydrolyzing] inhibitor (2R)-2... 2 1
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 16 6
Adenosine receptor A3 and Adenosine receptor A1 ligand (1R,2R,... 10 15
2-5A-dependent ribonuclease inhibitor [[(2R,3R,4R,5R)-5-(6-ami... 13 25
Adenosine receptor A1 ligand CHEMBL2112106 family 7 7
Adenosine receptor A1 and Adenosine receptor A2a ligand (1S,3S... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3R,... 1 5
Adenosine receptor A1 ligand 1-[6-(4-bicyclo[2.2.1]heptanylami... 3 0
Adenosine receptor A1 ligand CHEMBL258759 family 2 3
Adenosine receptor A1 and Adenosine receptor A2b ligand (2R,3R... 9 0
Adenosylhomocysteinase and Adenosine deaminase inhibitor AGN-P... 2 1
Adenosine receptor A2a and Adenosine receptor A2b ligand Cgs-2... 1 2
Adenosine receptor A2a and Adenosine receptor A2b ligand 3-[6-... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand (3R,4... 7 3
Adenosine receptor A3 and Adenosine receptor A2a ligand (2R,3R... 1 1
Putative Bioactive [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-di... 2 0
NS3 inhibitor sodium;[[[(2S,3R,4S,5S)-5-(4,8-diamino-6-iminoim... 1 0
Adenosylhomocysteinase inhibitor (E)-4-(6-aminopurin-9-yl)-2-m... 3 0
Carbohydrates and Carbohydrate Conjugates Metabolite 6-Thioxan... 1 0


External ID

Functional Category

Molecule Name

CFAMM00034840 DAP000565 Approved Drug Cladribine
CFAMM00034644 DAP000474 Approved Drug Adenosine triphosphate
CFAMM00035035 DAP000642 Approved Drug Vidarabine
CFAMM00034157 DAP001319 Approved Drug Adenosine monophosphate
CFAMM00034063 DAP000223 Approved Drug Adenosine
CFAMM00034600 DAP000849 Approved Drug Clofarabine
CFAMM00034842 DAP000567 Approved Drug Fludarabine
CFAMM00034613 DNAP001453 Approved Drug Fludarabine phosphate
CFAMM00034417 DCL000313 Clinical Trial Drug Tecadenoson
CFAMM00034906 DNC014827 Investigative Drug alpha,beta-methylene-dATP
CFAMM00034467 DNC007006 Investigative Drug 2-azido-N6-methyl-9-(beta-D-ribofuranosyl)adenine
CFAMM00034217 DNC003444 Investigative Drug 5'-Deoxy-5'-Methylthioadenosine
CFAMM00034928 DNC003239 Investigative Drug Adenosine-5'-Rp-Alpha-Thio-Triphosphate
CFAMM00034873 DNC002714 Investigative Drug 6-Chloropurine Riboside, 5'-Monophosphate
CFAMM00034734 DNC003910 Investigative Drug N6-CYCLOPENTYLADENOSINE
CFAMM00034504 DNC000091 Investigative Drug 5'-methylthioadenosine
CFAMM00034192 DNC003068 Investigative Drug 2'-Monophosphoadenosine-5'-Diphosphate
CFAMM00034453 DNC000530 Investigative Drug Decoyinine
CFAMM00034755 DNC002744 Investigative Drug Phosphomethylphosphonic Acid Adenosyl Ester
CFAMM00034673 DNC007769 Investigative Drug 5'-deoxy-5'-ureidoadenosine
CFAMM00034798 DNC000162 Investigative Drug Adenosine-5'-O-(2-thiodiphosphate)
CFAMM00034375 DNC008410 Investigative Drug NORARISTEROMYCIN
CFAMM00034902 DNC002669 Investigative Drug 8-Bromo-Adenosine-5'-Monophosphate
CFAMM00035019 DNC007158 Investigative Drug 2-(4-hydroxypent-1-yl)-N6-methoxyadenosine
CFAMM00034807 DNC009039 Investigative Drug 5'-Deoxy-5'-(N,N-dimethylamino)-8-methyladenosine
CFAMM00034445 DNC002456 Investigative Drug Adenosine-5'-Diphosphate
CFAMM00034073 DNC000074 Investigative Drug 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine
CFAMM00034717 DNC007160 Investigative Drug N6-methoxy-2-[2-(trimethylsilyl)ethynyl]adenosine
CFAMM00034989 DNC009040 Investigative Drug [(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
CFAMM00034501 DNC001235 Investigative Drug Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS)
CFAMM00035018 DNC007159 Investigative Drug 2-(5-cyano-1-pent-1-ynyl)-N6-methoxyadenosine
CFAMM00034150 DNC008109 Investigative Drug 2'-Me-tecadenoson
CFAMM00034617 DNC003222 Investigative Drug Purine Riboside
CFAMM00034716 DNC007162 Investigative Drug 2-ethynyl-N6-methoxyadenosine
CFAMM00034048 DNC003018 Investigative Drug Alpha,Beta-Methyleneadenosine-5'-Triphosphate
CFAMM00034431 DNC008111 Investigative Drug 2-chloro-N6-cyclopentyladenosine
CFAMM00034679 DNC008296 Investigative Drug ADENOSINETRIPHOSPHATE
CFAMM00034241 DNC007161 Investigative Drug 2-(hex-1-ynyl)-N6-methoxyadenosine
CFAMM00034443 DNC002455 Investigative Drug Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
CFAMM00034987 DNC009042 Investigative Drug 5'-Deoxy-5'-(N,N-dimethylamino)adenosine
CFAMM00034430 DNC008110 Investigative Drug 2-chloro-2'-C-methyl-tecadenoson
CFAMM00034835 DNC000262 Investigative Drug ATP
CFAMM00034280 DNC000962 Investigative Drug MRS-2179
CFAMM00034727 DNC002539 Investigative Drug Phosphoaminophosphonic Acid-Adenylate Ester
CFAMM00034605 DNC014565 Investigative Drug DEOXYADENOSINE
CFAMM00034316 DNC003147 Investigative Drug 3'-Oxo-Adenosine
CFAMM00034802 DNC000080 Investigative Drug 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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