CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD190
Family Name Alpha adrenergic receptor ligand catecholamine Phenylephrine Family
No. of Seeds 4 No. of Other Members 39
Family Centroid CFAMM00035048 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily adrenergic receptor ligand catecholamine Superfamily
Class Class 62

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand L-Tyrosine derivative Methyld... 2 3
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 11 21
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 1 8
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Membrane primary amine oxidase inhibitor 2-hydrazinyl-1-(4-met... 1 2
Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1
Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0
Alpha-1D adrenergic receptor ligand AGN-PC-0761MO family 1 0
Pol polyprotein inhibitor Tyr Aminodiol isostere family 1 0
Phenethylamines Metabolite Tyramine-O-sulfate Family 1 1
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00035048 DAP000224 Approved Drug Phenylephrine
CFAMM00035049 DAP000225 Approved Drug Metaraminol
CFAMM00035036 DCL000184 Clinical Trial Drug Octopamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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