CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD193
Family Name Alpha-1 adrenergic receptor ligand Dextroamphetamine derivative Midodrine Family
No. of Seeds 5 No. of Other Members 29
Family Centroid CFAMM00035329 Functional Category Approved Drug with Human Metabolite
Superfamily Alpha-1 adrenergic receptor ligand Dextroamphetamine derivative Phenylephrine analog Superfamily
Class Class 149

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Zucapsacin family 7 177
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
D(3) dopamine receptor Ligand U-99194A Family 7 33
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 11 21
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand N-... 1 4
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC13119705 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00035329 DAP000229 Approved Drug Midodrine
CFAMM00035336 DNC010693 Investigative Drug N-(3-(2-ethoxy-5-methoxyphenyl)propyl)acetamide
CFAMM00035335 DNC010692 Investigative Drug N-(3-(2,5-dimethoxyphenyl)propyl)acetamide
CFAMM00035334 DNC010691 Investigative Drug N-(3-(2-hydroxy-5-methoxyphenyl)propyl)acetamide
CFAMM00035333 DNC010694 Investigative Drug N-(3-(5-methoxy-2-propoxyphenyl)propyl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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