CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD194
Family Name Alpha-2 adrenergic receptor ligand opiate Meperidine Family
No. of Seeds 13 No. of Other Members 76
Family Centroid CFAMM00035373 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily opioid receptor, adrenergic receptor ligand opiate Acetylmethadol Meperidine Superfamily
Class Class 174

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Histamine H1 receptor Ligand Terfenadine Family 3 50
Histamine H1 receptor Ligand Levocabastine Family 1 1
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Muscarinic acetylcholine receptor M2 ligand Tropane alkaloid S... 7 16
Muscarinic acetylcholine receptor M5 ligand Tropane alkaloid A... 18 12
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor Ligand Oxyphencyclimine Family 1 2
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Muscarinic acetylcholine receptor M1 Ligand Oxyphenonium Family 12 5
Mu-type opioid receptor Ligand Anileridine Family 3 18
Mu-type opioid receptor Ligand Diphenoxylate Family 5 6
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Calcium-activated potassium channel subunit alpha-1 Ligand Tri... 1 10
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 8 30
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
C-C chemokine receptor type 5 ligand AC1L9U8N family 8 6
Trypsin-1 and Prothrombin inhibitor (3S,3aR,6aS)-3-benzyl-3,3a... 2 23
C-C chemokine receptor type 5 ligand (2R)-3-cyclopropyl-2-[(3S... 10 4
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 2-[4-[[1-(2,... 2 7
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 27
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
Sodium-dependent serotonin transporter and Transporter inhibit... 6 9
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Muscarinic acetylcholine receptor M3 ligand SureCN13330671 family 17 1
Muscarinic acetylcholine receptor M3 ligand (1,1-dimethylpiper... 7 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 0
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 4 17
Sigma non-opioid intracellular receptor 1 ligand methyl (1S,2R... 1 0
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Sodium-dependent serotonin transporter and Transporter inhibit... 2 4
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-07BZ08... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 4
Sodium-dependent dopamine transporter and Transporter inhibito... 1 1
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 17 43
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor me... 2 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 3 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 10 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Sodium-dependent dopamine transporter inhibitor AGN-PC-074TA8 ... 2 5
Carboxylic Acids and Derivatives Metabolite 3-Acetoxy-3-methyl... 2 0
Putative NP ZINC04084382 Family 8 0
3-[(4-benzoylpiperidin-1-ium-1-yl)methyl]-8a-methyl-5-methylid... 8 0
2,2-diphenylcyclopropane-1-carboxylate NP ZINC04029406 Family 5 0
Putative NP ZINC04073334 Family 30 0
[(1R,9aR)-1,2,3,4,5,6,7,8,9,9a-decahydroquinolizin-5-ium-1-yl]... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00035373 DAP000230 Approved Drug Meperidine
CFAMM00035376 CHEMBL554628 Bioactive AGN-PC-07C1SB
CFAMM00035386 CHEMBL542380 Bioactive AGN-PC-07BZ0D
CFAMM00035464 CHEMBL539252 Bioactive AGN-PC-07C1PV
CFAMM00035381 CHEMBL542630 Bioactive AGN-PC-07BZ1U
CFAMM00035451 CHEMBL543376 Bioactive Aprofen hydrochloride
CFAMM00035367 DNC000245 Investigative Drug Aprophen
CFAMM00035398 DNC000069 Investigative Drug 4-DAMP

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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