CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xanthine derivative Enprofylline Family
No. of Seeds 18 No. of Other Members 210
Family Centroid CFAMM00000112 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase, TNF inhibitor xanthine derivative Superfamily
Class Class 2

Cousin Family NamesSeedsMembers
Tumor necrosis factor inhibitor xanthine derivative Pentoxifyl... 5 69
xanthine alkaloid Theobromine family 6 10
DNA polymerase inhibitor guanosine analog Aciclovir Family 4 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xant... 3 7
Adenosine receptor A1 Ligand MK-7418 Family 21 116
Adenosine receptor A2a Ligand BG-9928 Family 8 11
UDP-N-acetylglucosamine 1-carboxyvinyltransferase Inhibitor RW... 1 0
Purine nucleoside phosphorylase Inhibitor 9-(5,5-difluoro-5-ph... 1 16
Purine nucleoside phosphorylase Inhibitor 8-iodo-guanine Family 2 3
Hypoxanthine-guanine-xanthine phosphoribosyltransferase Inhibi... 3 7
Adenosine receptor A1 Ligand 7-(3,6,9,12-tetraoxatricos-22-eny... 1 1
Purine nucleoside phosphorylase inhibitor [(3R,4S)-3-(2-amino-... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand NSC14... 1 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 8-(1-$... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand 1,3-d... 1 1
Dipeptidyl peptidase 4 inhibitor SureCN554974 family 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 0


External ID

Functional Category

Molecule Name

CFAMM00000053 DAP000868 Approved Drug Oxtriphylline
CFAMM00000112 DAP000597 Approved Drug Enprofylline
CFAMM00000062 DAP000613 Approved Drug Aminophylline
CFAMM00000271 DAP000002 Approved Drug Theophylline
CFAMM00000285 DNC004206 Investigative Drug 1-Cyclopentyl-3,7-dihydro-purine-2,6-dione
CFAMM00000215 DNC011840 Investigative Drug 1,3-Dipropyl-3,7-dihydro-purine-2,6-dione
CFAMM00000293 DNC011864 Investigative Drug 1,3-Diallyl-3,7-dihydro-purine-2,6-dione
CFAMM00000059 DNC004203 Investigative Drug 1-Butyl-3,7-dihydro-purine-2,6-dione
CFAMM00000108 DNC011930 Investigative Drug 1-METHYLXANTHINE
CFAMM00000257 DNC011871 Investigative Drug 1,3-Diisobutyl-3,7-dihydro-purine-2,6-dione
CFAMM00000090 DNC003762 Investigative Drug 1-Butyl-3-methyl-3,7-dihydro-purine-2,6-dione
CFAMM00000273 DNC002538 Investigative Drug 3-ISOBUTYL-1-METHYLXANTHINE
CFAMM00000167 DNC011866 Investigative Drug 1,3-Diethyl-3,7-dihydro-purine-2,6-dione
CFAMM00000124 DNC011886 Investigative Drug 3-Isopropyl-1-methyl-3,7-dihydro-purine-2,6-dione
CFAMM00000236 DNC003746 Investigative Drug 1-Methyl-3-propyl-3,7-dihydro-purine-2,6-dione
CFAMM00000254 DNC011877 Investigative Drug 1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione
CFAMM00000056 DNC004209 Investigative Drug 1-Allyl-3,7-dihydro-purine-2,6-dione
CFAMM00000278 DNC004200 Investigative Drug 1-Propyl-3,7-dihydro-purine-2,6-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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