CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD20
Family Name Leutinizing-hormone-releasing hormone inhibitor peptide Leuprolide Family
No. of Seeds 43 No. of Other Members 911
Family Centroid CFAMM00005363 Functional Category Approved Drug with Human Metabolite
Superfamily Peptide hormone receptor bindng peptide Superfamily
Class Class 20

Cousin Family NamesSeedsMembers
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
Epidermal Growth Factor family 111 209
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin receptor Ligand Insulin, Porcine Family 61 205
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Renin Inhibitor Remikiren Family 100 126
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Growth hormone receptor Ligand EP-51216 Family 34 390
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
CBP-501 family 7 8
AEZS-108 family 5 2
Eluxadoline family 4 85
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Renin Inhibitor Enalkiren Family 56 44
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Tyrosine kinase Inhibitor PKI166 Family 17 198
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Pol polyprotein inhibitor penicillin deriv. 71 family 1 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Placenta growth factor inhibitor CHEMBL1689479 family 4 1
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Relaxin-3 receptor 1 and Relaxin-3 receptor 2 ligand CHEMBL203... 4 1
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 3 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Gastrin/cholecystokinin type B receptor ligand CHEMBL2386886 f... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Melanocortin receptor 4 ligand CHEMBL2415084 family 3 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
KiSS-1 receptor ligand [2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S... 1 1
Neuropeptide Y receptor type 2 ligand CHEMBL411765 family 1 0
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Epidermal growth factor receptor ligand CHEMBL437469 family 1 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Growth hormone secretagogue receptor type 1 ligand CHEMBL52599... 1 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
E3 ubiquitin-protein ligase Mdm2 and Protein Mdm4 inhibitor CH... 2 1
Phospho-N-acetylmuramoyl-pentapeptide-transferase inhibitor (2... 1 1
Glucagon receptor ligand CHEMBL267876 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00005363 DAP000020 Approved Drug Leuprolide
CFAMM00005407 DAP001051 Approved Drug Nafarelin
CFAMM00005444 DNAP001563 Approved Drug Buserelin acetate
CFAMM00005586 DAP001446 Approved Drug Leuprorelin acetate
CFAMM00005644 DNAP001527 Approved Drug Triptorelin
CFAMM00005405 DAP001052 Approved Drug Gonadorelin
CFAMM00005134 DNAP001474 Approved Drug Deslorelin
CFAMM00005336 DNAP001530 Approved Drug Gonadoreline-6-d-trp acetate
CFAMM00005366 DAP000023 Approved Drug Goserelin
CFAMM00004962 DNAP001433 Approved Drug Histrelin
CFAMM00005275 CHEMBL384306 Bioactive CHEMBL384306
CFAMM00004848 CHEMBL1201199 Bioactive Leuprorelin
CFAMM00004875 CHEMBL412698 Bioactive CHEMBL412698
CFAMM00005197 CHEMBL411200 Bioactive CHEMBL411200
CFAMM00005842 CHEMBL412257 Bioactive CHEMBL412257
CFAMM00005471 CHEMBL214707 Bioactive CHEMBL214707
CFAMM00004835 CHEMBL499980 Bioactive Galanin (1-16)
CFAMM00005447 CHEMBL1689406 Bioactive CHEMBL1689406
CFAMM00004908 CHEMBL428320 Bioactive CHEMBL428320
CFAMM00004989 CHEMBL2370519 Bioactive (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-6-amino-1-[[(2S)-1-[[(2S)-1-[(2R)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CFAMM00005460 CHEMBL438652 Bioactive (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-2-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CFAMM00005357 CHEMBL438096 Bioactive CHEMBL438096
CFAMM00005384 CHEMBL1007 Bioactive CHEBI:5520
CFAMM00005467 CHEMBL410938 Bioactive CHEMBL410938
CFAMM00004935 DNC011441 Investigative Drug JMV 1802
CFAMM00005330 DNC009642 Investigative Drug GWTLNSAGYLLGPHAV-NH2
CFAMM00005422 DNC010529 Investigative Drug GWTLNSAGYLLGPRHYINLITRQRY-CONH2
CFAMM00005103 DNC010531 Investigative Drug GWTLNSAGYLLGPrPKPQQwFwLL-CONH2
CFAMM00005182 DNC004784 Investigative Drug [Tyr4]Bombesin
CFAMM00005129 DNC011484 Investigative Drug JMV 1799
CFAMM00005658 DNC011472 Investigative Drug JMV 1803
CFAMM00005421 DNC010528 Investigative Drug GWTLNSAGYLLGPPPGFSPFR-CONH2
CFAMM00005521 DND000014 Investigative Drug Goserelin
CFAMM00005328 DNC004779 Investigative Drug [N40,Pro1,Tyr4,Nle 14]BB
CFAMM00005848 DNC012701 Investigative Drug LHRH
CFAMM00005193 DNC006106 Investigative Drug c[Thr-Tyr-Thr-His-DNaf-Arg-Trp-Thr-Ile-Pro]
CFAMM00004970 DNC006044 Investigative Drug pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-Pro-Gly-NH2
CFAMM00005418 DNC010527 Investigative Drug GWTLNSAGYLLGPPPALALA-CONH2
CFAMM00005192 DNC006107 Investigative Drug c[Ser-Tyr-Thr-His-Dphe-Arg-Trp-Thr-Ile-Pro]
CFAMM00005185 DNC004780 Investigative Drug Universal ligand
CFAMM00005184 DNC004781 Investigative Drug [N40,Pro1,Tyr4]BB
CFAMM00005342 DNC008997 Investigative Drug GALANIN
CFAMM00005730 DNC011459 Investigative Drug JMV 1719

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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