CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family
No. of Seeds 10 No. of Other Members 90
Family Centroid CFAMM00036772 Functional Category Approved Drug with Natural Product
Superfamily adrenergic receptor ligand catecholamine Superfamily
Class Class 62

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Muscarinic acetylcholine receptor M1 Ligand GSK573719 Family 2 0
Acolbifene family 10 115
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 1 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 1
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 20 7
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 5 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 3 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Phenylalanine--tRNA ligase alpha subunit inhibitor TCMDC-14030... 1 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5


External ID

Functional Category

Molecule Name

CFAMM00036728 DAP000937 Approved Drug Ritodrine
CFAMM00036772 DAP000248 Approved Drug Salbutamol
CFAMM00036670 DAP000947 Approved Drug Salmeterol
CFAMM00036774 CHEMBL489553 Bioactive AC1LEMBZ
CFAMM00036689 CHEMBL1085395 Bioactive acetic acid;2-(hydroxymethyl)-4-[(1R)-1-hydroxy-2-[6-(2-phenylmethoxyethoxy)hexylamino]ethyl]phenol
CFAMM00036724 CHEMBL1084891 Bioactive acetic acid;4-[(1R)-2-[6-[2-[(3,5-dimethylphenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol
CFAMM00036694 CHEMBL552398 Bioactive BR-AEA
CFAMM00036700 DCL000687 Clinical Trial Drug Albuterol sulfate
CFAMM00036685 DNC000873 Investigative Drug Levalbuterol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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