CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Benzodiazepine receptor ligand benzodiazepine derivative Fludiazepam Family
No. of Seeds 11 No. of Other Members 78
Family Centroid CFAMM00005956 Functional Category Approved Drug with Human Metabolite
Superfamily Benzodiazepine receptor, GABA receptor binding benzodiazepine derivatives Superfamily
Class Class 21

Cousin Family NamesSeedsMembers
Benzodiazepine receptor ligand benzodiazepine derivative Oxaze... 4 0
Benzodiazepine receptor Ligand Clorazepate Family 2 3
Gamma-aminobutyric acid receptor ligand benzodiazepine derivat... 2 8
Gamma-aminobutyric acid receptor subunit alpha-1 ligand benzod... 1 2
Benzodiazepine receptor ligand benzodiazepine derivative Fluni... 2 22
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 1 19
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 8
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4796979 f... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Tankyrase-2 inhibitor 7-(2-chlorophenyl)-4-methyl-1H-quinolin-... 1 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 4
Oxytocin receptor ligand N-[1-[2-[[(2S)-1-amino-3-(3,4-dichlor... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Trypanothione reductase inhibitor 3-(6-chloro-2-methyl-4-pheny... 9 1
Trypanothione reductase inhibitor 1-[4-[2-(6-chloro-2-methyl-4... 1 0
Putative NP ZINC55466512 Family 2 0


External ID

Functional Category

Molecule Name

CFAMM00006010 DAP000242 Approved Drug Flurazepam
CFAMM00005956 DAP000934 Approved Drug Fludiazepam
CFAMM00005943 DAP000679 Approved Drug Halazepam
CFAMM00005948 DAP000689 Approved Drug Prazepam
CFAMM00005900 DAP000021 Approved Drug Diazepam
CFAMM00005936 CHEMBL9689 Bioactive 7-chloro-5-(2,6-dichlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
CFAMM00005929 CHEMBL523 Bioactive Nordiazepam
CFAMM00005974 CHEMBL268254 Bioactive Delorazepam
CFAMM00005995 CHEMBL276821 Bioactive RO-223294
CFAMM00005905 DNC014696 Investigative Drug DIAZEPAM HYDROCHLORIDE
CFAMM00005959 DNC000995 Investigative Drug NB-3040

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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