Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118 5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680 Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44 Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397 Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140 Squalene monooxygenase Inhibitor Naftifine Family 8 32 Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25 Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41 Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45 Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33 Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31 Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17 Substance-P receptor Ligand Vestipitant Family 14 137 Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15 Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23 Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30 D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27 Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15 Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10 Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4 Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1 Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9 Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1 Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1 5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1 D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0 5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0 Histamine H3 receptor ligand SureCN1641166 family 3 0 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0 Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6 Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0 Prostatic acid phosphatase inhibitor Phosphonic acid, [1-napht... 1 0 Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00037001
CHEMBL19841
Bioactive
AC1NQHWS CFAMM00037009
CHEMBL38369
Bioactive
SureCN141415 CFAMM00037024
CHEMBL380827
Bioactive
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(2-phenylphenyl)methanamine CFAMM00037006
CHEMBL141537
Bioactive
(2R)-N-benzyl-5-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine CFAMM00037022
CHEMBL1788369
Bioactive
(1S,4S)-N-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00036997
CHEMBL189973
Bioactive
SureCN5995221 CFAMM00037021
CHEMBL39591
Bioactive
(1R,4S)-N-methyl-4-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine CFAMM00036996
CHEMBL408368
Bioactive
N-benzyl-1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-amine CFAMM00037013
CHEMBL1788367
Bioactive
(1S,4S)-N-methyl-4-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00037027
CHEMBL1743849
Bioactive
(1R,4S)-N-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00037012
CHEMBL59400
Bioactive
CHEMBL59400 CFAMM00037025
CHEMBL38120
Bioactive
TAMETRALINE CFAMM00037000
CHEMBL140092
Bioactive
Diphenyl isoindoline CFAMM00037023
CHEMBL168116
Bioactive
SureCN9643747 CFAMM00037003
CHEMBL1200776
Bioactive
Cinacalcet hydrochloride CFAMM00037020
CHEMBL1788368
Bioactive
Tametraline HCl CFAMM00037026
CHEMBL1743844
Bioactive
(1R,4S)-4-(4-fluorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00037004
HMDB60891
Human Metabolite
N-Desmethylterbinafine CFAMM00037017
DNC006807
Investigative Drug
1-(2-(naphthalen-2-yl)-1-phenylethyl)piperazine CFAMM00036999
DNC008272
Investigative Drug
N-ethyl-2,2,2-triphenylacetamide CFAMM00037014
DNC011273
Investigative Drug
FENDILINE CFAMM00037002
13277373
Patent Compound
AGN-PC-00LTGK CFAMM00037019
57090393
Patent Compound
AGN-PC-0BI6R9 CFAMM00037018
54173689
Patent Compound
AGN-PC-0A45W5 CFAMM00037031
12949918
Patent Compound
naphthalen-1-yl(phenyl)methanamine CFAMM00037030
57149943
Patent Compound
AGN-PC-0C2JAT CFAMM00037008
10594784
Patent Compound
CFAMM00037029
54335497
Patent Compound
AGN-PC-0A5MHE CFAMM00037028
19876147
Patent Compound
SureCN9731285 CFAMM00036994
57148291
Patent Compound
SureCN9312683
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
48688 visits since 2014 .........
Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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