Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118 5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680 Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44 Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397 Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140 Squalene monooxygenase Inhibitor Naftifine Family 8 32 Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25 Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41 Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45 Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33 Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31 Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17 Substance-P receptor Ligand Vestipitant Family 14 137 Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15 Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23 Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30 D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27 Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15 Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10 Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4 Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1 Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9 Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1 Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1 5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1 D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0 5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0 Histamine H3 receptor ligand SureCN1641166 family 3 0 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0 Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6 Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0 Prostatic acid phosphatase inhibitor Phosphonic acid, [1-napht... 1 0 Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00037001 CHEMBL19841 Bioactive
AC1NQHWS CFAMM00037009 CHEMBL38369 Bioactive
SureCN141415 CFAMM00037024 CHEMBL380827 Bioactive
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(2-phenylphenyl)methanamine CFAMM00037006 CHEMBL141537 Bioactive
(2R)-N-benzyl-5-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine CFAMM00037022 CHEMBL1788369 Bioactive
(1S,4S)-N-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00036997 CHEMBL189973 Bioactive
SureCN5995221 CFAMM00037021 CHEMBL39591 Bioactive
(1R,4S)-N-methyl-4-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine CFAMM00036996 CHEMBL408368 Bioactive
N-benzyl-1-[(6-fluoronaphthalen-2-yl)methyl]piperidin-4-amine CFAMM00037013 CHEMBL1788367 Bioactive
(1S,4S)-N-methyl-4-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00037027 CHEMBL1743849 Bioactive
(1R,4S)-N-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00037012 CHEMBL59400 Bioactive
CHEMBL59400 CFAMM00037000 CHEMBL140092 Bioactive
Diphenyl isoindoline CFAMM00037023 CHEMBL168116 Bioactive
SureCN9643747 CFAMM00037003 CHEMBL1200776 Bioactive
Cinacalcet hydrochloride CFAMM00037020 CHEMBL1788368 Bioactive
Tametraline HCl CFAMM00037026 CHEMBL1743844 Bioactive
(1R,4S)-4-(4-fluorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride CFAMM00037025 CHEMBL38120 Bioactive
TAMETRALINE CFAMM00037004 HMDB60891 Human Metabolite
N-Desmethylterbinafine CFAMM00037017 DNC006807 Investigative Drug
1-(2-(naphthalen-2-yl)-1-phenylethyl)piperazine CFAMM00036999 DNC008272 Investigative Drug
N-ethyl-2,2,2-triphenylacetamide CFAMM00037014 DNC011273 Investigative Drug
FENDILINE CFAMM00037018 54173689 Patent Compound
AGN-PC-0A45W5 CFAMM00037031 12949918 Patent Compound
naphthalen-1-yl(phenyl)methanamine CFAMM00037030 57149943 Patent Compound
AGN-PC-0C2JAT CFAMM00037008 10594784 Patent Compound
CFAMM00037029 54335497 Patent Compound
AGN-PC-0A5MHE CFAMM00037028 19876147 Patent Compound
SureCN9731285 CFAMM00036994 57148291 Patent Compound
SureCN9312683 CFAMM00037002 13277373 Patent Compound
AGN-PC-00LTGK CFAMM00037019 57090393 Patent Compound
AGN-PC-0BI6R9
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
