Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720 Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686 Acetylcholinesterase Inhibitor Tacrine Family 12 515 Histamine H1 receptor Ligand Pheniramine Family 10 380 Histamine H1 receptor Ligand Triprolidine Family 19 316 Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68 Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60 Prothrombin Inhibitor Ximelegatran Family 8 157 5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66 Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242 D(1B) dopamine receptor Ligand LE-300 Family 65 452 Amg 423 family 7 47 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44 Tryptase Inhibitor Babim Family 12 90 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17 Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66 D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48 Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109 Platelet-derived growth factor receptor alpha and Platelet-der... 5 48 Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117 Epidermal growth factor receptor Ligand PD-158780 Family 98 89 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22 Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11 Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8 Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26 Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24 Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9 Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7 NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3 Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13 RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4 Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16 Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2 Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108 Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4 Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23 Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10 Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3 Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15 Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2 Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3 Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2 Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2 Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0 Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2 Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22 Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27 Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7 Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2 Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5 Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0 Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0 Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7 Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0 Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0 D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2 Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0 Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00038529
CHEMBL415879
Bioactive
1,10-phenanthroline CFAMM00038546
CHEMBL2417635
Bioactive
4-[(6-phenylpyridin-3-yl)methyl]isoquinoline CFAMM00038554
CHEMBL196007
Bioactive
Hydroxy Varenicline CFAMM00038584
CHEMBL197690
Bioactive
SureCN4960851 CFAMM00038557
CHEMBL198278
Bioactive
CHEMBL198278 CFAMM00038593
CHEMBL1083447
Bioactive
SureCN3455985 CFAMM00038555
CHEMBL2205810
Bioactive
3-methyl-1,10-phenanthroline CFAMM00038570
CHEMBL593442
Bioactive
4,7-Dimethyl-1,10-phenanthroline CFAMM00038577
CHEMBL316589
Bioactive
4-Methyl-1,10-phenanthroline CFAMM00038551
CHEMBL69644
Bioactive
Tyrphostin AG 1385 CFAMM00038566
CHEMBL1288013
Bioactive
NSC-24047 CFAMM00038595
CHEMBL248644
Bioactive
9-phenyl-2,7-phenanthroline CFAMM00038541
CHEMBL197022
Bioactive
AGN-PC-075XJY CFAMM00038587
CHEMBL198659
Bioactive
AGN-PC-075XJX CFAMM00038533
CHEMBL99384
Bioactive
3,4,7,8-Tetramethyl-1,10-phenanthroline CFAMM00038565
CHEMBL108216
Bioactive
6,7-dimethyl-N-phenylquinoxalin-2-amine CFAMM00038591
CHEMBL196006
Bioactive
AGN-PC-075XK7 CFAMM00038569
CHEMBL345360
Bioactive
6-(2-methylphenyl)-8-(3-nitrophenyl)-1,7-naphthyridine CFAMM00038560
CHEMBL2164341
Bioactive
1-(3-pyridin-2-ylphenyl)piperazine CFAMM00038536
CHEMBL1171991
Bioactive
AGN-PC-07ZQME CFAMM00038582
CHEMBL2177515
Bioactive
6-(3-azabicyclo[3.3.1]non-6-en-7-yl)quinoxaline CFAMM00038534
CHEMBL1916344
Bioactive
4-(2,4-difluorophenyl)-8-(2-methylphenyl)-7-oxido-1,7-naphthyridin-7-ium CFAMM00038579
CHEMBL1669424
Bioactive
N-methyl-2-[3-[(1R)-1-pyrazin-2-ylethyl]-1H-inden-2-yl]-N-(pyridin-2-ylmethyl)ethanamine CFAMM00038539
CHEMBL199183
Bioactive
AGN-PC-075XK2 CFAMM00038580
HMDB32981
Human Metabolite
2,3-Diphenylpyrazine CFAMM00038586
HMDB33178
Human Metabolite
5-Methylquinoxaline CFAMM00038564
HMDB15398
Human Metabolite
Varenicline CFAMM00038567
ZINC00295505
Natural Product
8-isopropyl-3-methyl-5,6-dihydro-4H-pyrazino[3,2,1-jk]carbazol-3-ium iodide CFAMM00038585
22391374
Patent Compound
N-Ethyl-8-quinolinamine CFAMM00038537
23345
Patent Compound
1-Benzylisoquinoline CFAMM00038545
589030
Patent Compound
4-methyl-1,5-naphthyridine CFAMM00038576
53771658
Patent Compound
AGN-PC-09YKV9 CFAMM00038590
12887789
Patent Compound
AGN-PC-00JY3B CFAMM00038553
89356
Patent Compound
AC1L3HOR CFAMM00038568
53876926
Patent Compound
AGN-PC-09ZYIE CFAMM00038544
54309425
Patent Compound
AGN-PC-0A8RCS CFAMM00038559
54120875
Patent Compound
AGN-PC-0A35GT CFAMM00038589
252644
Patent Compound
Dibenzo[f,h]quinoxaline CFAMM00038575
54024095
Patent Compound
AGN-PC-0A1VZW CFAMM00038535
13823481
Patent Compound
SureCN10379194 CFAMM00038552
15224414
Patent Compound
SureCN213063 CFAMM00038581
9991330
Patent Compound
SureCN9375658 CFAMM00038596
53977469
Patent Compound
AGN-PC-03DZNE CFAMM00038558
54300901
Patent Compound
AGN-PC-0A8NDK CFAMM00038573
20154719
Patent Compound
1-ethylphenazine CFAMM00038588
57183460
Patent Compound
AGN-PC-0BP18R CFAMM00038550
22148879
Patent Compound
6-Methylquinolin-3-amine CFAMM00038556
282849
Patent Compound
3-phenylquinoline CFAMM00038571
54061339
Patent Compound
ethane;5-methylquinoline CFAMM00038532
593686
Patent Compound
1-Ethylisoquinoline CFAMM00038549
9800794
Patent Compound
SureCN6968215 CFAMM00038578
10956218
Patent Compound
SureCN1078553 CFAMM00038592
67472
Patent Compound
4,7-Phenanthroline CFAMM00038538
15040652
Patent Compound
5,6-ISOQUINOLINEDIAMINE
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
48707 visits since 2014 .........
Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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