Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720 Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686 Acetylcholinesterase Inhibitor Tacrine Family 12 515 Histamine H1 receptor Ligand Pheniramine Family 10 380 Histamine H1 receptor Ligand Triprolidine Family 19 316 Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68 Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60 Prothrombin Inhibitor Ximelegatran Family 8 157 5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66 Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242 D(1B) dopamine receptor Ligand LE-300 Family 65 452 Amg 423 family 7 47 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44 Tryptase Inhibitor Babim Family 12 90 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17 Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66 D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48 Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109 Platelet-derived growth factor receptor alpha and Platelet-der... 5 48 Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117 Epidermal growth factor receptor Ligand PD-158780 Family 98 89 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22 Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11 Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8 Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26 Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24 Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9 Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7 NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3 Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13 RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4 Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16 Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2 Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108 Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4 Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23 Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10 Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3 Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15 Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2 Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3 Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2 Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2 Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0 Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2 Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22 Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27 Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7 Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2 Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5 Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0 Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0 Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fl... 6 7 Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0 Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4 Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0 D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2 Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0 Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00038557 CHEMBL198278 Bioactive
CHEMBL198278 CFAMM00038593 CHEMBL1083447 Bioactive
SureCN3455985 CFAMM00038546 CHEMBL2417635 Bioactive
4-[(6-phenylpyridin-3-yl)methyl]isoquinoline CFAMM00038529 CHEMBL415879 Bioactive
1,10-phenanthroline CFAMM00038554 CHEMBL196007 Bioactive
Hydroxy Varenicline CFAMM00038584 CHEMBL197690 Bioactive
SureCN4960851 CFAMM00038551 CHEMBL69644 Bioactive
Tyrphostin AG 1385 CFAMM00038566 CHEMBL1288013 Bioactive
NSC-24047 CFAMM00038595 CHEMBL248644 Bioactive
9-phenyl-2,7-phenanthroline CFAMM00038541 CHEMBL197022 Bioactive
AGN-PC-075XJY CFAMM00038587 CHEMBL198659 Bioactive
AGN-PC-075XJX CFAMM00038533 CHEMBL99384 Bioactive
3,4,7,8-Tetramethyl-1,10-phenanthroline CFAMM00038565 CHEMBL108216 Bioactive
6,7-dimethyl-N-phenylquinoxalin-2-amine CFAMM00038555 CHEMBL2205810 Bioactive
3-methyl-1,10-phenanthroline CFAMM00038570 CHEMBL593442 Bioactive
4,7-Dimethyl-1,10-phenanthroline CFAMM00038577 CHEMBL316589 Bioactive
4-Methyl-1,10-phenanthroline CFAMM00038534 CHEMBL1916344 Bioactive
4-(2,4-difluorophenyl)-8-(2-methylphenyl)-7-oxido-1,7-naphthyridin-7-ium CFAMM00038579 CHEMBL1669424 Bioactive
N-methyl-2-[3-[(1R)-1-pyrazin-2-ylethyl]-1H-inden-2-yl]-N-(pyridin-2-ylmethyl)ethanamine CFAMM00038539 CHEMBL199183 Bioactive
AGN-PC-075XK2 CFAMM00038591 CHEMBL196006 Bioactive
AGN-PC-075XK7 CFAMM00038569 CHEMBL345360 Bioactive
6-(2-methylphenyl)-8-(3-nitrophenyl)-1,7-naphthyridine CFAMM00038560 CHEMBL2164341 Bioactive
1-(3-pyridin-2-ylphenyl)piperazine CFAMM00038536 CHEMBL1171991 Bioactive
AGN-PC-07ZQME CFAMM00038582 CHEMBL2177515 Bioactive
6-(3-azabicyclo[3.3.1]non-6-en-7-yl)quinoxaline CFAMM00038580 HMDB32981 Human Metabolite
2,3-Diphenylpyrazine CFAMM00038586 HMDB33178 Human Metabolite
5-Methylquinoxaline CFAMM00038564 HMDB15398 Human Metabolite
Varenicline CFAMM00038567 ZINC00295505 Natural Product
8-isopropyl-3-methyl-5,6-dihydro-4H-pyrazino[3,2,1-jk]carbazol-3-ium iodide CFAMM00038596 53977469 Patent Compound
AGN-PC-03DZNE CFAMM00038558 54300901 Patent Compound
AGN-PC-0A8NDK CFAMM00038573 20154719 Patent Compound
1-ethylphenazine CFAMM00038588 57183460 Patent Compound
AGN-PC-0BP18R CFAMM00038550 22148879 Patent Compound
6-Methylquinolin-3-amine CFAMM00038571 54061339 Patent Compound
ethane;5-methylquinoline CFAMM00038556 282849 Patent Compound
3-phenylquinoline CFAMM00038532 593686 Patent Compound
1-Ethylisoquinoline CFAMM00038549 9800794 Patent Compound
SureCN6968215 CFAMM00038578 10956218 Patent Compound
SureCN1078553 CFAMM00038592 67472 Patent Compound
4,7-Phenanthroline CFAMM00038538 15040652 Patent Compound
5,6-ISOQUINOLINEDIAMINE CFAMM00038585 22391374 Patent Compound
N-Ethyl-8-quinolinamine CFAMM00038537 23345 Patent Compound
1-Benzylisoquinoline CFAMM00038545 589030 Patent Compound
4-methyl-1,5-naphthyridine CFAMM00038576 53771658 Patent Compound
AGN-PC-09YKV9 CFAMM00038590 12887789 Patent Compound
AGN-PC-00JY3B CFAMM00038553 89356 Patent Compound
AC1L3HOR CFAMM00038568 53876926 Patent Compound
AGN-PC-09ZYIE CFAMM00038544 54309425 Patent Compound
AGN-PC-0A8RCS CFAMM00038559 54120875 Patent Compound
AGN-PC-0A35GT CFAMM00038575 54024095 Patent Compound
AGN-PC-0A1VZW CFAMM00038589 252644 Patent Compound
Dibenzo[f,h]quinoxaline CFAMM00038552 15224414 Patent Compound
SureCN213063 CFAMM00038535 13823481 Patent Compound
SureCN10379194 CFAMM00038581 9991330 Patent Compound
SureCN9375658
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
