CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFAD222
Family Name Omega 1 Benzodiazepine receptor Ligand Zaleplon Family
No. of Seeds 6 No. of Other Members 589
Family Centroid CFAMM00039336 Functional Category Approved Drug with Natural Product
Superfamily Omega 1 Benzodiazepine receptor Ligand Zaleplon Superfamily
Class Class 195

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Histamine H1 receptor Ligand Mizolastine Family 14 603
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
HER Inhibitor AC480 Family 4 67
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor PF-0048... 2 13
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
SCH-900776 family 8 14
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 9
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 9 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Type-2 angiotensin II receptor Ligand SC-50560 Family 3 84
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Type-2 angiotensin II receptor Ligand SC-55634 Family 8 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 55
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
D(3) dopamine receptor and D(2) dopamine receptor ligand (1S,5... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-met... 7 12
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 7 21
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Transient receptor potential cation channel subfamily V member... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Histamine H3 receptor ligand SureCN4025673 family 4 2
Histamine H3 receptor ligand SureCN4018269 family 1 0
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1B angiotensin II receptor ligand 2-[2-butyl-3-[[4-[2-(2H... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-a... 8 11
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Insulin-like growth factor 1 receptor and Insulin receptor lig... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Glucose-dependent insulinotropic receptor ligand 4-({Ethyl-[1-... 6 12
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 2 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Type-1 angiotensin II receptor and Peroxisome proliferator-act... 6 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Vasopressin V1a receptor ligand 2-[4-[4-[(3-chlorophenyl)methy... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(7-aminop... 1 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2,... 4 4
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-... 4 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[2-chloro-5-[[3-cya... 2 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Tyrosine-protein kinase JAK2 inhibitor [4-[[5-(1-ethylpyrazol-... 2 3
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Cathepsin K inhibitor SureCN4141224 family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 2
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 5 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Mitogen-activated protein kinase 14 inhibitor SureCN294394 family 2 6
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A3 ligand SureCN6716937 family 1 0
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Metabotropic glutamate receptor 5 ligand AGN-PC-075GDI family 1 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Fatty-acid amide hydrolase 1 and Liver carboxylesterase 1 inhi... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
Aurora kinase A inhibitor SureCN2205392 family 2 2
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07R77D fa... 2 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Muscarinic acetylcholine receptor M1 and Cytochrome P450 2C9 l... 2 5
Corticotropin-releasing factor receptor 1 ligand 3-[6-(dimethy... 1 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN415... 1 2
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 26
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1
Glucocorticoid receptor ligand N-ethyl-4-fluoro-N-[3,3,3-trifl... 1 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor 3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00039336 DAP000266 Approved Drug Zaleplon
CFAMM00038729 CHEMBL2409175 Bioactive N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]acetamide
CFAMM00039369 CHEMBL2409183 Bioactive N-[5-[[3-cyano-7-[(1-methylpyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]acetamide
CFAMM00039056 CHEMBL230353 Bioactive AGN-PC-0766PJ
CFAMM00039287 CHEMBL2409173 Bioactive 5-[(1-acetyl-2,3-dihydroindol-6-yl)amino]-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
CFAMM00038731 CHEMBL2409181 Bioactive N-[5-[[3-cyano-7-(cyclobutylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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