CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD224
Family Name Oxytocin receptor Ligand Oxytocin Family
No. of Seeds 30 No. of Other Members 182
Family Centroid CFAMM00039621 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Oxytocin receptor and Vasopressin V2 receptor Binder Superfamily
Class Class 18

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Atrial natriuretic peptide receptor 1 Ligand Nesiritide Family 6 111
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Zucapsacin family 7 177
Thymopentin family 20 133
B2 bradykinin receptor Ligand Labradimil Family 1 1
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Thymosin Beta-4 family 8 30
Plitidepsin family 15 5
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Flovagatran family 12 546
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Prothrombin Inhibitor Efegatran Family 9 47
Neprilysin Inhibitor Thiorphan Family 41 68
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Caspase-1 Inhibitor Yvad Family 1 0
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 9
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Tyrosine--tRNA ligase, cytoplasmic inhibitor (2S)-2-[[(2S)-2-a... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Pol polyprotein inhibitor AC1LADQG family 7 1
NS3 inhibitor CHEMBL201121 family 1 4
C-X-C chemokine receptor type 4 ligand CHEMBL2012526 family 4 8
Plasminogen inhibitor (2S)-2-acetamido-5-(diaminomethylideneam... 1 0
Vasopressin V1a receptor ligand (10S,13S,16S,19S,22S)-N-[(2S)-... 1 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Oxytocin receptor ligand (2S)-N-[(2R)-1-[2-[[5-amino-1-[[1-ami... 4 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Neurotensin receptor type 1 ligand (2S)-2-[[(2S,3S)-2-[[(2S)-2... 2 1
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
C-X-C chemokine receptor type 4 ligand CHEMBL2372990 family 3 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Angiotensin-converting enzyme inhibitor Rentiapril family 1 7
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
Growth factor receptor-bound protein 2 ligand 2-[[(9S,12S,15S,... 2 3
1,3-beta-glucan synthase component GSC2 inhibitor CHEMBL407395... 1 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Signal transducer and activator of transcription 3 inhibitor [... 3 1
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00039621 DAP001156 Approved Drug Oxytocin
CFAMM00039516 DAP001029 Approved Drug Urofollitropin
CFAMM00039514 DAP000269 Approved Drug Carbetocin
CFAMM00039644 CHEMBL352836 Bioactive Oxytocin Trisulfide
CFAMM00039536 CHEMBL331109 Bioactive ALMPLYACI
CFAMM00039504 CHEMBL435716 Bioactive DEMOXYTOCIN
CFAMM00039589 CHEMBL2369425 Bioactive Cystathionine Oxytocin
CFAMM00039635 CHEMBL1630522 Bioactive (2S)-1-[(4R,7S,10S,13S,16S,19R)-4-amino-16-(2-amino-2-oxoethyl)-13-(3-amino-3-oxopropyl)-10-[(2S)-butan-2-yl]-7-[(4-hydroxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-2-selena-6,9,12,15,18-pentazacycloicosane-19-carbonyl]-N-[(1S)-1-[(2-amino-2-oxoethyl)amino]-3-methylbutyl]pyrrolidine-2-carboxamide
CFAMM00039459 CHEMBL1790200 Bioactive CHEMBL1790200
CFAMM00039634 CHEMBL1630523 Bioactive (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1-thia-2-selena-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-1-[(2-amino-2-oxoethyl)amino]-3-methylbutyl]pyrrolidine-2-carboxamide
CFAMM00039458 CHEMBL1790201 Bioactive CHEMBL1790201
CFAMM00039552 CHEMBL353396 Bioactive Deaminooxytocin Trisulfide
CFAMM00039583 DNC013165 Investigative Drug d[Orn4,Orn8]VP
CFAMM00039609 DNC003009 Investigative Drug N-(Sulfanylacetyl)Tyrosylprolylmethioninamide
CFAMM00039582 DNC013166 Investigative Drug d[Orn4,Lys8]VP
CFAMM00039608 DNC013175 Investigative Drug d[Cha4,Orn8]VP
CFAMM00039650 DNC007695 Investigative Drug [Pip7]OT
CFAMM00039607 DNC013174 Investigative Drug d[Cha4,Dab8]VP
CFAMM00039649 DNC007692 Investigative Drug [Aib7]OT
CFAMM00039606 DNC013173 Investigative Drug d[Cha4,Dap8]VP
CFAMM00039648 DNC007691 Investigative Drug [Gly(But)7]OT
CFAMM00039533 DNC009384 Investigative Drug cyclo(1,10)H-EIYDPGDDIK-OH
CFAMM00039605 DNC013171 Investigative Drug d[Leu4,Lys8]VP
CFAMM00039654 DNC013176 Investigative Drug d[Cha4,Lys8]VP
CFAMM00039473 DNC006702 Investigative Drug Demotensin 1
CFAMM00039585 DNC013168 Investigative Drug d[Leu4,Dap8]VP
CFAMM00039604 DNC013170 Investigative Drug d[Leu4,Orn8]VP
CFAMM00039584 DNC013169 Investigative Drug d[Leu4,Dab8]VP
CFAMM00039498 DNC006701 Investigative Drug Demotensin 2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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