CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD225
Family Name Peroxisome proliferator-activated receptor alpha Ligand Fenofibrate Family
No. of Seeds 3 No. of Other Members 127
Family Centroid CFAMM00039784 Functional Category Approved Drug with Natural Product
Superfamily Peroxisome proliferator-activated receptor alpha Ligand Fenofibrate Superfamily
Class Class 197

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Solute carrier family 12 member 1 Inhibitor Ethacrynic Acid Fa... 3 42
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 2 14
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Prostaglandin D2 receptor 2 Ligand 2-(4-chloro-2-cyclohexylphe... 7 25
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Peroxisome proliferator-activated receptor alpha and Peroxisom... 7 6
Cocaine esterase and Liver carboxylesterase 1 inhibitor 2-Chlo... 1 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 8
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 5
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (3R,... 1 28
Transthyretin inhibitor AGN-PC-046XQV family 1 6
Prostaglandin D2 receptor 2 ligand 2-[2-[2-(2-chlorophenyl)eth... 1 0
Endothelin-1 receptor and Endothelin B receptor ligand SureCN8... 3 1
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
Metabotropic glutamate receptor 2 ligand AGN-PC-00DDSM family 1 0
Estrogen receptor beta and Estrogen receptor ligand (5-hydroxy... 1 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 1 1
Aldose reductase inhibitor 2-(7-chloro-2-oxochromen-4-yl)aceti... 1 0
NP Agn-pc-05wmi6 Family 2 0
NP (z)-2-((2-methyl-2h-chromen-3-yl)methylene)-3-oxo-2,3-dihyd... 74 1
orobenzoate NP 3-(2-methoxyphenyl)-2-methyl-4-oxo-4h-chromen-7... 22 0
2-(trifluoromethyl)chromen-4-one NP ZINC01929476 Family 25 0
1-benzofuran-3-one NP ZINC02424004 Family 22 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00039784 DAP000270 Approved Drug Fenofibrate
CFAMM00039787 DNCL002936 Clinical Trial Drug ABT-335
CFAMM00039833 DNC013905 Investigative Drug FENOFIBRIC ACID

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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