CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD229
Family Name Retinoid X receptor Ligand Bexarotene Family
No. of Seeds 7 No. of Other Members 492
Family Centroid CFAMM00040309 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Retinoid X receptor Ligand Bexarotene Superfamily
Class Class 201

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Danthron family 11 141
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
DNA topoisomerase 1 Inhibitor Beta-lapachone Family 3 66
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family 4 13
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Nicotinate-nucleotide pyrophosphorylase [carboxylating] Inhibi... 2 119
Beta-lactamase Inhibitor 4-carboxyphenylboronic Acid Family 1 1
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Liver carboxylesterase 1 Inhibitor 2,2-dimethoxy-1,2-diphenyl-... 1 16
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
Neutrophil elastase Inhibitor 3,4-dichloroisocoumarin Family 1 5
Liver carboxylesterase 1 Inhibitor Acenanthrene-9,10-dione Family 2 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Protein kinase C delta type and Protein kinase C alpha type In... 4 105
Collagenase 3 and Macrophage metalloelastase Inhibitor 5-(4'-c... 4 43
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
DNA polymerase Inhibitor 3-cis-p-coumaroyl Maslinic Acid Family 3 38
Retinoic acid receptor gamma and Retinoic acid receptor beta l... 2 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 2-[9-... 2 15
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Free fatty acid receptor 1 and Free fatty acid receptor 4 liga... 1 7
Retinoic acid receptor RXR-beta and Retinoic acid receptor RXR... 1 3
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 3
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 2 16
Retinoic acid receptor gamma and Retinoic acid receptor beta l... 1 6
RAC-alpha serine/threonine-protein kinase inhibitor CHEMBL4754... 2 17
Arachidonate 15-lipoxygenase inhibitor SureCN9469035 family 6 40
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 1 2
Retinoic acid receptor RXR-beta and Retinoic acid receptor RXR... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-[4-(2,4-di... 3 4
Peroxisome proliferator-activated receptor gamma ligand SureCN... 3 3
Prostaglandin E2 receptor EP2 subtype ligand 4-[2-[(1R,3R)-3-h... 1 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 10
Retinal dehydrogenase 1 and Microtubule-associated protein tau... 1 7
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 6 13
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Beta-lactamase inhibitor CHEMBL1358094 family 1 10
Aromatase inhibitor [(8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo... 2 10
Integrase inhibitor AGN-PC-00QHSA family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 1 1
Microtubule-associated protein tau and Putative fructose-1,6-b... 1 1
Free fatty acid receptor 1 ligand 3-[4-[2-(3-formylphenyl)ethy... 1 0
Tyrosine-protein phosphatase non-receptor type 1 ligand AGN-PC... 1 1
Indanes Metabolite (R)-Pterosin B Family 5 8
Putative NP ZINC14410655 Family 6 4
[(1S,2S,5R)-2-hydroxy-2-methyl-5-prop-1-en-2-ylcyclohexyl] ben... 1 2
(1S)-1-hydroxy-1,4-dimethyl-2,3-dihydrocyclopenta[b]anthracene... 1 1
3-methyl-1-oxo-4H-isochromene-3-carboxylate NP Methyl 3-methyl... 4 1
4-hydroxy-2-(4-methoxycarbonylphenyl)-4-methyl-6-oxocyclohexan... 15 2
carboxylate NP ZINC04026424 Family 3 7
methylbenzoate NP 7-oxocyclohepta-1,3,5-trien-1-yl 3-methylben... 2 1
ethoxy-[6-[ethoxy(oxido)methylidene]-3,7-dioxo-1,5-dihydro-s-i... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00040309 DAP000276 Approved Drug Bexarotene
CFAMM00040048 DNC007690 Investigative Drug methyl 2-(naphthalen-2-yl)benzoate
CFAMM00040060 DNC003336 Investigative Drug 2,6-DICARBOXYNAPHTHALENE
CFAMM00040358 DNC002530 Investigative Drug CD564
CFAMM00040398 DNC003489 Investigative Drug 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
CFAMM00040357 DNC002532 Investigative Drug BMS184394
CFAMM00040412 DNC002541 Investigative Drug TTNPB

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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