CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD23
Family Name Sodium-dependent dopamine transporter inhibitor substituted phenethylamine derivative Methylphenidate family
No. of Seeds 22 No. of Other Members 416
Family Centroid CFAMM00006254 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Sodium-dependent dopamine transporter inhibitor substituted phenethylamine derivative Methylphenidate Superfamily
Class Class 23

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Opioid receptor Ligand Methadone Family 3 39
Histamine H1 receptor Ligand Levocabastine Family 1 1
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Muscarinic acetylcholine receptor M2 ligand Tropane alkaloid S... 7 16
Muscarinic acetylcholine receptor M5 ligand Tropane alkaloid A... 18 12
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family 19 144
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Muscarinic acetylcholine receptor M1 Ligand Oxyphenonium Family 12 5
Mu-type opioid receptor Ligand Anileridine Family 3 18
Mu-type opioid receptor Ligand Diphenoxylate Family 5 6
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Cytochrome P450 2D6 Inhibitor Glutethimide Family 1 1
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
Dopamine reuptake Inhibitor Amineptine Family 2 5
Dopamine reuptake and Noradrenergic re-uptake Inhibitor GSK372... 7 61
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Pitolisant family 4 24
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Flovagatran family 12 546
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cruzipain Inhibitor WRR-204 Family 18 35
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl ... 11 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 7
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 8 30
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 11 20
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
C-C chemokine receptor type 5 ligand AC1L9U8N family 8 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 8
C-C chemokine receptor type 5 ligand (2R)-3-cyclopropyl-2-[(3S... 10 4
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 1
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 0
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 27
Growth hormone secretagogue receptor type 1 ligand SureCN63170... 1 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 2
Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl... 4 27
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
Sodium-dependent serotonin transporter and Transporter inhibit... 6 9
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 1
Muscarinic acetylcholine receptor M3 ligand SureCN13330671 family 17 1
Muscarinic acetylcholine receptor M3 ligand (1,1-dimethylpiper... 7 1
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 1 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 0
Sigma non-opioid intracellular receptor 1 ligand methyl (1S,2R... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 7 2
Transporter and Sodium-dependent serotonin transporter inhibit... 8 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 11 2
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... 4 0
Sodium-dependent serotonin transporter and Transporter inhibit... 2 4
Neprilysin inhibitor benzyl (2S)-2-[[2-(sulfanylmethyl)-3,4-di... 4 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Transporter and Sodium-dependent serotonin transporter inhibit... 4 0
Free fatty acid receptor 1 ligand (3R,4R)-3-(3,4-dichloropheny... 1 0
Sigma non-opioid intracellular receptor 1 and Muscarinic acety... 2 3
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-07BZ08... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 4
Transporter and Sodium-dependent dopamine transporter inhibito... 1 5
Transporter and Sodium-dependent dopamine transporter inhibito... 2 1
Sodium-dependent dopamine transporter and Transporter inhibito... 1 1
Sodium- and chloride-dependent GABA transporter 1 inhibitor (3... 17 43
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor me... 2 0
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 3 0
Sigma non-opioid intracellular receptor 1 and Muscarinic acety... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 1-... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand (2S,... 5 5
Cathepsin B and Cathepsin L1 inhibitor benzyl (2S)-2-benzyl-3-... 1 0
Sodium- and chloride-dependent GABA transporter 1 inhibitor Su... 10 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Putative NP ZINC04084382 Family 8 0
7-phenyl-1,3-diazaadamantan-6-ol NP ZINC32124180 Family 5 0
N-[(4S)-2,2-dimethyloxan-4-yl]-4-methyl-3-phenylpentanamide NP... 4 0
[(1R,9aR)-1,2,3,4,5,6,7,8,9,9a-decahydroquinolizin-5-ium-1-yl]... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00006254 DAP000024 Approved Drug Methylphenidate
CFAMM00006285 CHEMBL1722 Bioactive METHYLPHENIDATE HYDROCHLORIDE
CFAMM00006205 DNCL003073 Clinical Trial Drug NWP06
CFAMM00006384 DNC014456 Investigative Drug (+/-)-threo-N-(5-Phenylpentyl)methylphenidate
CFAMM00006159 DNC014474 Investigative Drug N-Benzylmethylphenidate
CFAMM00006189 DNC014482 Investigative Drug (+/-)-threo-Ritalinol methyl ether
CFAMM00006383 DNC014452 Investigative Drug (+/-)-threo-N-(3-Phenylpropyl)methylphenidate
CFAMM00006151 DNC007035 Investigative Drug 1-phenyl-1-(piperidin-2-yl)propan-2-one
CFAMM00006158 DNC014472 Investigative Drug (+/-)-threo-3',5'-Dichloromethylphenidate
CFAMM00006389 DNC014459 Investigative Drug (+/-)-threo-N-Allylmethylphenidate
CFAMM00006157 DNC014471 Investigative Drug (+/-)-threo-3',5'-Dimethylmethylphenidate
CFAMM00006387 DNC014455 Investigative Drug (+/-)-threo-N-(4-Phenylbutyl)methylphenidate
CFAMM00006118 DNC013266 Investigative Drug threo-ritalinol methyl ether hydrochloride
CFAMM00006186 DNC014486 Investigative Drug (+/-)-threo-Benzylphenidate
CFAMM00006386 DNC014454 Investigative Drug (+/-)-threo-N-(2-Phenylethyl)methylphenidate
CFAMM00006238 DNC014449 Investigative Drug (+/-)-threo-N-Propargylmethylphenidate
CFAMM00006117 DNC013264 Investigative Drug erythro-3,4-dichloromethylphenidate hydrochloride
CFAMM00006185 DNC014487 Investigative Drug (+/-)-threo-Ritalinol acetate
CFAMM00006161 DNC014476 Investigative Drug DEXMETHYLPHENIDATE
CFAMM00006191 DNC014489 Investigative Drug (+/-)-threo-4'-Ethylmethylphenidate
CFAMM00006385 DNC014457 Investigative Drug (+/-)-threo-N-(6-Phenylhexyl)methylphenidate
CFAMM00006184 DNC014485 Investigative Drug (+/-)-threo-N-Methyl-30-methylmethylphenidate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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