CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD234
Family Name D(1B) dopamine receptor Ligand Apomorphine Family
No. of Seeds 30 No. of Other Members 271
Family Centroid CFAMM00041068 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily D(1B) dopamine receptor Ligand Apomorphine Superfamily
Class Class 205

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
u-type opioid receptor ligand opiate opiate analog Oxymorphone... 22 105
Nicotinic acetylcholine receptor alpha subunit Ligand benzylis... 4 18
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha-2 adrenergic receptor Ligand Oxymetazoline Family 5 4
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Nalfurafine Hcl family 33 107
Eptazocine Hbr family 6 8
Glaziovine family 1 4
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
D(2) dopamine receptor Ligand N-0923 Family 6 41
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-br... 2 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Delta-type opioid receptor Ligand Longanine Family 3 0
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
D(2) dopamine receptor and D(1A) dopamine receptor Ligand SK&F... 8 8
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
D(2) dopamine receptor Ligand (s)-secoantioquine Family 1 10
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
D(1A) dopamine receptor ligand DOXANTHINE family 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Mu-type opioid receptor ligand Morphine-6-glucuronide family 7 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
D(3) dopamine receptor ligand S 14297 family 1 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
Delta-type opioid receptor and Kappa-type opioid receptor liga... 6 0
Transient receptor potential cation channel subfamily V member... 14 7
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
D(2) dopamine receptor and D(1A) dopamine receptor ligand (6aR... 2 4
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 7 0
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (2R,... 1 0
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
D(1A) dopamine receptor and D(1) dopamine receptor ligand Sure... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Alpha-2A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
Putative NP ZINC12858318 Family 42 0
Putative NP ZINC12660125 Family 8 0
7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline NP ZINC33345333... 21 3
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00041068 DAP000281 Approved Drug Apomorphine
CFAMM00041394 DNC007399 Investigative Drug predicentrine methiodide
CFAMM00041073 DNC014092 Investigative Drug N-Ethyl-2-phenylnorapomorphine hydrochloride
CFAMM00040925 DNC013604 Investigative Drug 3-Iodoboldine
CFAMM00041111 DNC011876 Investigative Drug R-N-PROPYLNORAPOMORPHINE
CFAMM00041405 DNC013486 Investigative Drug 1,2,3,7,12,12a-hexahydro-1-aza-pleiadene-5,6-diol
CFAMM00041391 DNC013478 Investigative Drug PREDICENTRINE
CFAMM00041180 DNC013520 Investigative Drug (R)-(-)-N-propyl-2-methoxy-11-hydroxynoraporphine
CFAMM00041171 DNC013350 Investigative Drug (R)-(-)-10-methyl-11-hydroxyaporphine
CFAMM00041304 DNC013665 Investigative Drug 2-{[R-(-)-Apomorphine-2'-oxy]ethoxy}-ethanol
CFAMM00041179 DNC013521 Investigative Drug (R)-(-)-N-ethyl-2-methoxy-11-hydroxynoraporphine
CFAMM00041106 DNC012276 Investigative Drug Ro-21-7767
CFAMM00041400 DNC007397 Investigative Drug N-methyllaurotetanine methiodide
CFAMM00041185 DNC010201 Investigative Drug DIHYDREXIDINE
CFAMM00041077 DNC014094 Investigative Drug N-Propyl-2-phenylnorapomorphine hydrochloride
CFAMM00041178 DNC013522 Investigative Drug (R)-(-)-2-methoxy-11-hydroxyaporphine
CFAMM00041303 DNC013664 Investigative Drug [R-(-)-Apomorphine-2-yl]-(2'-hydroxy-ethyl)ether
CFAMM00041011 DNC000241 Investigative Drug Apomorphine SL
CFAMM00041223 DNC009505 Investigative Drug N-methyllaurotetanine
CFAMM00041399 DNC007395 Investigative Drug boldine methiodide
CFAMM00041034 DNC014093 Investigative Drug N-Propyl-2-methylnorapomorphine hydrochloride
CFAMM00041237 DNC013626 Investigative Drug (R)-(-)-2-Phenyl-apomorphine hydrochloride
CFAMM00041177 DNC013523 Investigative Drug (R)-(-)-2-methoxy-N-npropylnorapomorphine
CFAMM00041075 DNC014091 Investigative Drug N-Ethyl-2-methylnorapomorphine hydrochloride
CFAMM00041236 DNC013625 Investigative Drug (R)-(-)-2-Methyl-apomorphine hydrochloride
CFAMM00041386 DNC013976 Investigative Drug NORBOLDINE
CFAMM00041176 DNC013524 Investigative Drug 2-methoxyapomorphine
CFAMM00041395 DNC007398 Investigative Drug BOLDINE
CFAMM00040996 DNC009357 Investigative Drug 11-Hydroxy-N-propylnoraporphine
CFAMM00041234 DNC012717 Investigative Drug (S)APOMORPHINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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