CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD238
Family Name Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family
No. of Seeds 8 No. of Other Members 178
Family Centroid CFAMM00042085 Functional Category Approved Drug with Natural Product
Superfamily Monoamine reuptake inhibitor Dibenzazepine Superfamily
Class Class 207

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Calmodulin Inhibitor Aprindine Family 1 4
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Zicronapine family 43 62
WAY-162545 family 2 4
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Transient receptor potential cation channel subfamily V member... 6 33
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Cholinesterase Inhibitor (-)-debromoflustramine B Family 2 14
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Sodium-dependent noradrenaline transporter inhibitor 3-[1-(2-f... 2 13
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Prelamin-A/C and Alpha-2A adrenergic receptor ligand AMITRAZ f... 1 5
Bloom syndrome protein and Cytochrome P450 3A4 inhibitor CHEMB... 1 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 3
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[[4... 7 11
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand 4-[(... 2 3
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Histamine H3 receptor ligand SureCN3052824 family 4 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Androgen receptor ligand 1-[4-[3-[4-[(3,3-dimethyl-2-oxobutyl)... 1 2
C-C chemokine receptor type 3 ligand CHEMBL300905 family 2 1
Monoglyceride lipase and Fatty-acid amide hydrolase 1 inhibito... 1 4
Alkaloids and Derivatives Metabolite (+)-Aspidospermidine Family 1 5
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0
3,3,5,5,7,10c-hexamethyl-1,2,3,5,5a,6,10b,10c-octahydrocyclope... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00042086 DAP001153 Approved Drug Trimipramine
CFAMM00042085 DAP001154 Approved Drug Imipramine
CFAMM00042015 DAP000293 Approved Drug Mianserin
CFAMM00042088 DAP001151 Approved Drug Desipramine
CFAMM00042126 CHEMBL1696 Bioactive Desipramine hydrochloride
CFAMM00042004 CHEMBL173315 Bioactive CHEMBL173315
CFAMM00042124 CHEMBL1692 Bioactive Imipramine hydrochloride
CFAMM00042001 CHEMBL252719 Bioactive (S)-mianserin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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