CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFAD239
Family Name 5-hydroxytryptamine receptor 3A Ligand Granisetron Family
No. of Seeds 26 No. of Other Members 212
Family Centroid CFAMM00042184 Functional Category Approved Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 3A Ligand Granisetron Superfamily
Class Class 208

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
HIV protease Inhibitor BIT225 Family 2 2
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
Smoothened homolog Inhibitor LY2940680 Family 3 18
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Coagulation factor X Inhibitor SN429 Family 23 100
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A1 and Adenosine receptor A2a Ligand FK-838... 4 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Poly [ADP-ribose] polymerase 1 Inhibitor 2-phenylpyrazolo-[1,5... 1 1
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Ripaze... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Smoothened homolog inhibitor SureCN1091571 family 2 2
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 11
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07PRSG fa... 6 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Glucocorticoid receptor ligand N-(2-amino-2-oxoethyl)-3-[4-[[(... 6 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Mitogen-activated protein kinase 8 inhibitor (2S)-2-[[(2S)-2-[... 3 0
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 2 2
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
5-hydroxytryptamine receptor 3A ligand N-[(1S,5S)-9-methyl-9-a... 1 0
5-hydroxytryptamine receptor 3A ligand 1-[3-[[5-(dimethylamino... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
5-hydroxytryptamine receptor 4 ligand N-[(1R,5S)-8-[2-hydroxy-... 4 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 2 1
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 1 0
5-hydroxytryptamine receptor 3A ligand 5-hydroxy-1-methyl-N-[(... 4 2
5-hydroxytryptamine receptor 4 ligand 4-[2-[4-[[(1-propan-2-yl... 1 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Cathepsin S inhibitor N-[(S)-[1-(1-cyanocyclopropyl)triazol-4-... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 and Macr... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Neutrophil elastase and Chymotrypsinogen B inhibitor 1-(3-meth... 1 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (2... 5 5
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Coagulation factor X inhibitor DPC 423 derivative, 8 family 1 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN4298966 f... 10 1
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
Serine/threonine-protein kinase Chk1 inhibitor PDK1 inhibitor,... 1 4
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 8 inhibitor 5-[(6-chloro-1-ox... 5 7
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand 3-[[... 1 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Histone deacetylase 1 inhibitor N-hydroxy-N',N'-bis[2-(1H-inda... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Alkaline phosphatase, tissue-nonspecific isozyme inhibitor N-(... 1 10
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Calcitonin gene-related peptide type 1 receptor ligand [(2R)-3... 2 0
Cathepsin L1 and Cathepsin L2 inhibitor 5-tert-butyl-N-[(2S)-1... 2 5
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
Metabotropic glutamate receptor 1 ligand AGN-PC-07CPMZ family 1 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 3 2
Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-(3-methyl-6,7-... 6 1
Serine/threonine-protein kinase D1 inhibitor 3-[5-[3-bromo-4-(... 1 1
Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-[3-(4-chloroph... 2 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
TGF-beta receptor type-1 ligand Methyl 4-(4-(3-(pyridin-2-yl)-... 1 2
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Rho-associated protein kinase 2 and Cytochrome P450 3A4 inhibi... 3 5
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Cannabinoid receptor 1 ligand AGN-PC-073K3Q family 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Apoptosis regulator Bcl-2 and Bcl2-associated agonist of cell ... 3 3
Vascular endothelial growth factor receptor 2 and Vascular end... 5 9
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00042184 DAP000295 Approved Drug Granisetron
CFAMM00042362 CHEMBL2179705 Bioactive N-[[1-[2-(4-nitrophenyl)ethyl]piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide;oxalic acid
CFAMM00042472 CHEMBL2179697 Bioactive 1-propan-2-yl-N-[[1-(2-pyridin-2-ylethyl)piperidin-4-yl]methyl]indazole-3-carboxamide;hydrochloride
CFAMM00042368 CHEMBL2179703 Bioactive N-[[1-[3-(methylamino)-3-oxopropyl]piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide;hydrochloride
CFAMM00042471 CHEMBL2179696 Bioactive N-[(1-benzylpiperidin-4-yl)methyl]-1-propan-2-ylindazole-3-carboxamide;hydrochloride
CFAMM00042367 CHEMBL2179702 Bioactive N-[[1-[2-(methanesulfonamido)ethyl]piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide;hydrochloride
CFAMM00042192 CHEMBL289469 Bioactive granisetron
CFAMM00042470 CHEMBL2059580 Bioactive N-[(1R,5S)-8-[6-[methyl(propan-2-yl)amino]hexyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042366 CHEMBL2179701 Bioactive (Z)-but-2-enedioic acid;N-[[1-[3-(dimethylamino)propyl]piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042176 CHEMBL1628633 Bioactive [3H]GRANISETRON
CFAMM00042434 CHEMBL2177130 Bioactive N-[[1-(2-phenylethyl)piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide;hydrochloride
CFAMM00042230 CHEMBL2059590 Bioactive N-[(1R,5S)-8-[2-(4-acetylpiperazin-1-yl)ethyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042442 CHEMBL552796 Bioactive N-(piperidin-4-ylmethyl)-1-propan-2-ylindazole-3-carboxamide
CFAMM00042365 CHEMBL2179700 Bioactive N-[[1-(2-morpholin-4-ylethyl)piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide;hydrochloride
CFAMM00042251 CHEMBL2059577 Bioactive N-[(1R,5S)-8-(2-hydroxy-3-piperidin-1-ylpropyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042374 CHEMBL2059589 Bioactive N-[(1R,5S)-8-[2-(4-methylsulfonylpiperazin-1-yl)ethyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042364 CHEMBL2179699 Bioactive N-[[1-(2-cyclohexylethyl)piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide;hydrochloride
CFAMM00042476 CHEMBL598184 Bioactive 1-(3-aminopropyl)-N-[(1S,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide
CFAMM00042208 CHEMBL38582 Bioactive SureCN2086084
CFAMM00042467 CHEMBL2059584 Bioactive N-[(1R,5S)-8-[6-[4-(methanesulfonamidomethyl)piperidin-1-yl]hexyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042250 CHEMBL2059579 Bioactive N-[(1R,5S)-8-[2-hydroxy-3-[methyl(propan-2-yl)amino]propyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042363 CHEMBL2179706 Bioactive N-[[1-[2-(4-aminophenyl)ethyl]piperidin-4-yl]methyl]-1-propan-2-ylindazole-3-carboxamide;hydrochloride
CFAMM00042466 CHEMBL2059586 Bioactive N-[(1R,5S)-8-[6-(4-methylsulfonylpiperazin-1-yl)hexyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042249 CHEMBL2059578 Bioactive N-[(1R,5S)-8-(6-piperidin-1-ylhexyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylindazole-3-carboxamide
CFAMM00042244 DCL000728 Clinical Trial Drug BP4.879a
CFAMM00042445 DNC000348 Investigative Drug BRL 43694A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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